Merck + Co., Inc.

John D Prugh

George D Hartman

Melissa S Egbertson

Wasyl Halczenko

Mark E Duggan

William F Hoffman

William A Bolhofer

Clarence S Rooney

Ben C Askew

Nathan C Ihle

Albert A Deana

Wasyl Halezenko

Fibrinogen receptor antagonists

Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##

Novel HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed. ##STR1##

Novel HMG-CoA reductase inhibitors

Novel 5-carbamoylthieno[2,3-b]thiophene-2-sulfonamides and derivatives thereof are prepared in reactions of 5-methoxycarbonylthieno-[2,3-b]thiophene-2-sulfonamide with alkylamines, alkoxyalkylamines and hydroxyalkylamines. These compounds are useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.

5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active

Aromatic sulfonamides useful in the treatment of elevated intraocular pressure having the structural formula: ##STR1## wherein A, R, R.sup.1, and R.sup.2 are as hereinafter defined, as well as the pharmaceutically and ophthalmologically acceptable salts thereof.

Substituted thieno[2,3-b]thiophene-2-sulfonamides as antiglaucoma agents

Novel substituted thieno[3,2-b]thiophene-2-sulfonamides are prepared by novel synthetic processes. These compounds are useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.

Substituted thieno[3,2-b]thiophene-2-sulfonamides as topically active

Thieno[2,3-b]thiophene-2-sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.

Thieno[2,3-b]furan-2-sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.

Substituted thieno[2,3-B]furan-2-sulfonamides as antiglaucoma agents

Totally synthetic analogs of the known inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, compactin and mevinolin, are prepared from a chiral synthon derived from D-glucose which has the same chirality as the natural products.

3-O-benzyl-2,4,6-tridooxy-6-iodo-alpha-D-erythro-hexopyranide useful for

Certain 6-(substituted-naphthyl)hydrocarbyl-4-hydroxytetrahydropyran-2-ones are unexpectedly potent in the treatment of familial hypercholesterolemia, hyperlipemia and atherosclerosis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase).

Synthetic analogs of mevinolin

Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme

Heterocyclic carbamates are disclosed which have potent gastric secretion inhibitory properties. The heterocyclic substituent is a pyridyl group or a 6-membered heterocycle with two nitrogen heteroatoms, which may be optionally substituted. Further substituents on the carbamate nitrogen and oxygen atoms are also disclosed. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.

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Chalfont, PA, United States of America

John D Prugh