Yale University

Neumora Therapeutics, Inc.

Blackthorn Therapeutics, Inc.

John D Murray

Alan Anticevic

William J Martin

Jie Lisa Ji

Described herein are example methods and systems for neuro-behavioral relationships in dimensional geometric bedding (N-BRIDGE), which includes a comprehensive, data-driven analytic framework for mapping the multi-dimensional relationships between neural and behavioral features in humans N-BRIDGE allows mapping of variations along newly-defined data-driven behavioral dimensions that capture the geometry of behavioral/symptom variation to variation in specific neural features. A method for treating a patient based on neuro-behavioral mapping includes receiving, from a user interface of a computing device, behavioral data of a patient corresponding to mental health or cognitive status of the patient, predicting, by at least one processor of the computing device, a neural feature map for the patient representative of neural data based on the behavioral data, determining, by the at least one processor, a therapeutic associated with the neural feature map, and treating the patient with the therapeutic associated with the neural feature map.

Systems and methods for neuro-behavioral relationships in dimensional geometric embedding (N-BRIDGE)

The present tools and methods for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject. These tools and methods relates to a genotype and neurophenotype topography-based approach for analyzing brain neuroimaging and gene expression maps to identify drug targets associated with neurobehavioral phenotypes and, conversely, neurobehavioral phenotypes associated with potential drug targets, to develop rational design and application of pharmacological therapeutics for brain disorders, and to provide methods and tools for treatment of subjects in need of neurological therapy.

Methods and tools for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject

The present disclosure relates to computer generated topographies from computer correlations of neurobehavioral phenotype mapping data and gene expression mapping data. Neurobehavioral phenotype mapping data is obtained for a selected phenotype and correlated with gene expression mapping data for one or more genes to define a phenotype-gene pair topography for each phenotype-gene pair. A score for each phenotype-gene pair is determined based on the correlation. The scores are used to identify genes, or drug targets, associated with the respective gene of the respective phenotype-gene pair. Conversely, gene expression mapping data is obtained for a selected gene and correlated with neurobehavioral phenotype mapping data for one or more phenotypes to define a gene-phenotype topography for each gene-phenotype pair. A score for each gene-phenotype pair is determined based on the correlation. The scores are used to identify a phenotype associated with the respective phenotype-gene pair.

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New Haven, CT, United States of America

John D Murray