The United States of America As Represented by the Department of Health

Other

The United States of America As Represented by the Secretary of

John D Minna

Frank F Cuttitta

Edward A Sausville

James L Mulshine

Jean Viallet

The present invention discloses anti-bombesin monoclonal antibody and a method of detecting autocrine growth factor. A method and kit for screening and controlling growth of human SCLC has also been disclosed.

Inhibition of small cell lung cancer cell growth in vivo using

The invention is to a method of treating malignancies with cholera toxin after determining if labelled beta subunit cholera toxin binds to the tissue.

Inhibition of malignant cells having G.sub.M1 ganglo-side sites by

Monoclonal antibody specific for bombesin

Monoclonal antibodies 703D4 and 704A1 detect human non-small cell lung cancer (non-SCLC) and distinguish non-SCLC from all other types of lung cancer and normal tissue cells. These two antibodies may be utilized in kit form to distinguish non-SCLC from other forms of lung cancer. These monoclonal antibodies bind to S.sup.35 methionine-incorporating protein doublets under reduced and unreduced conditions. The determinants bound by these antibodies on the 31 kiladalton protein are independent of each other as determined in radiolabelled competition assays.

Monoclonal antibodies against non small cell lung cancer

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Bethesda, MD, United States of America

John D Minna