Burroughs Wellcome Co.

John D McDermed

Anjaneyulu S Tadepalli

Vincent H Chang

Kevin P Hurley

John W Findlay

Geoffrey G Coker

Harold S Freeman

Arthur P Phillips

Gerald M McKenzie

Anti-hypertensive tetralins

The present invention is concerned with compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-4 alkoxy;

Anti-hypertensive sulfonanilides

The present invention is concerned with compounds of formula (I) ##STR1## wherein R.sub.1 is hydrogen;

Antihypertensive sulfonanilides

The compound 2-[10-(2-Dimethylaminopropyl)-7-fluoro-2-phenothiazinyl]-2-methylpropionic acid or a pharmaceutically acceptable salt thereof. The compound or salt are useful as antihistamines.

Fluoropheno-thiazine and pharmaceutical use

The compound 2-[10-(2-Dimethylaminopropyl)-2-phenothiazinyl]-2-methylpropionic acid or a pharmaceutically acceptable salt thereof. The compound and salt are useful as antihistamines.

Branched chain phenothiazine

5,6-Dialkoxy-2-tetralones (I) are disclosed as useful intermediates in the synthesis of 2-amino-5,6-dialkoxytetralins (III) and 2-amino-5,6-dihydroxytetralins (IV). Compounds of the groups III and IV are potent emetics.

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Chapel Hill, NC, United States of America

John D McDermed