Columbia University

Other

John D Loike

Samuel C Silverstein

Peter P Lee

Sadna Budhu

David Holzer

Francesco DiVirgilio

Suzanne Hickman

A method is provided, inter alia, for treating a subject suffering from an infectious or neoplastic disease with immunotherapy. The method includes determining the critical concentration of immune cells required to treat or eradicate an infectious or neoplastic disease in the subject using an in vitro assay of the present invention; and administering to the subject the critical concentration of immune cells determined in the assay.

Methods for treating an infectious or neoplastic disease

A method is provided for treating a subject suffering from an infectious or neoplastic disease with immunotherapy. The method comprises determining the critical concentration of immune cells required to treat or eradicate an infectious or neoplastic disease in the subject using an in vitro assay of the present invention; and administering to the subject the critical concentration of immune cells determined in the assay.

An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. Also provided is an in vitro assay for determining the effect of an activated CD8T-cell on a sensitized melanoma cell. A method for improving the specific cytolytic activity (SCA) of an immune cell comprising contacting an immune cell with an antigen and an antigen-independent pro-inflammatory agent is provided. A method for ex vivo expansion of antigen-specific CD8T-cells with enhanced specific cytolytic activity (SCA) comprising culturing the antigen-specific CD8T-cells in a suitable culture media comprising an amino acid. An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. A method of treating a subject suffering from an infectious or neoplastic disease with immuno therapy is described.

Assays for determining the effect of an immune cell on a cell from an infectious or neoplastic disease

This invention provides methods of delivering an antigen to an Class I or Class II MHC receptors to induce immunity against the antigen in a subject having a disease. This invention also provides methods of delivering an antigen to an Class II or class I MHC receptor to supress immunity against the antigen in a subject having a disease.

Method for using phagocytic particles and ATP receptors to deliver antigens to MHC class I receptors to induce immunity against microbial pathogens or tumors or to suppress immunity

Described is a method of producing mammalian ADH in plants and a method of producing mammalian ALDH in plants. The ADH and ALDH is preferably of human origin and preferably human class IV .sigma. ADH and human ALDH2. Mammalian ADH and ALDH is recovered from the plants and packaged with NAD and a suitable buffer as a pill, paste, or food snack. The composition is taken orally or otherwise before engaging in social drinking to prevent or ameliorate the effects of alcohol consumption.

Mammalian alcohol dehydrogenase and aldehyde dehydrogenase production in

An agent capable of inhibiting signalling mediated by a .beta..sub.1 integrin cell surface receptor of leukocyte cells will treat a bacterial infection associated with a surface of a foreign body over and around which fibrin has been deposited, or a malignant tumor over and around which tenascin has been deposited. In addition, coating a foreign body with a fibrinolytic agent will prevent chronic bacterial infection associated with the surface of the foreign body. Furthermore, an agent capable of stimulating signalling mediated by a .beta..sub.1 integrin cell surface receptor of leukocyte cells will treat chronic inflammation.

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Jamaica, NY, United States of America

John D Loike