The Cleveland Clinic Foundation

Aptargroup, Inc.

Trinity Health-michigan

John D Hall

Cameron C McIntyre

Jaimie M Henderson

Christopher R Butson

Ali R Rezai

Barry D Kuban

Ken Baker

Kenneth R Jonkman

Frank G Shellock

Christopher C Knowlton

Kenneth B Baker

Timothy L Fitzgerald

Michael P Ashbrook

This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.

Method and device for displaying predicted volume of influence

A flexible, resilient, self-sealing slit-type valve () is provided with a configuration that minimizes the difference between the pressure differential at which the valve opens and the pressure differential at which the valve () closes. The valve () includes a peripheral mounting portion () and a valve head () connected thereto. The valve head () has an interior surface () and an exterior surface () which each has a recessed configuration such that the thickness between the exterior surface () and interior surface () is thinner at the center on the longitudinal axis () of the valve () than at a radially outward location.

Valve

This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, a target volume of activation (VOA) can be received, a test VOA can be simulated, and at least one of a target electrode location or parameter can be provide using a relationship between the target VOA and the test VOA.

Brain stimulation models, systems, devices, and methods

Method and system for displaying a volume of influence by an electrode inserted in neural tissue

Method and device for displaying predicted volume of influence with patient-specific atlas of neural tissue

A vessel occluder is disposed inside a principal blood vessel for occluding tributary blood vessels inside the principal blood vessel while still allowing blood to flow through the principal vessel. The vessel occluder includes a support structure and associated membrane that can be collapsed for insertion into the principal vessel. Once inserted at the desired location the support structure is allowed to expand, forcing the membrane to contact the inner walls of the vessel with sufficient force to occlude the openings of the tributary vessels.

Blood vessel occluder and method of use

This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as amplitude, pulsewidth, frequency, pulse morphology, electrode contact selection or location, return path electrode selection, pulse polarity, etc. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, the non-uniform tissue conductivity is obtained from diffusion tensor imaging (DTI) data. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence. In another example, a neuron or axon model is used to calculate the volume of influence without computing the second difference of the electric potential distribution.

This document discusses brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as electrode contact selection or location. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence. In another example, a neuron or axon model is used to calculate the volume of influence without computing the second difference of the electric potential distribution.

Tissue stimulation models, systems, devices, and methods

A device for modulating a volume of neural tissue comprising: a cannula having a proximal end, a distal end, and a lumen extending to at least the distal end, an actuator mechanism at least partially disposed in the lumen of the cannula; a plurality of leads having at least one electrode disposed thereon, the plurality of leads being coupled to the actuator mechanism to reciprocate between a retracted position wherein the plurality of leads are radially constrained within the lumen and an extended position; and a guide provided at the distal end of the cannula to deflect the plurality of leads radially outwardly into the neural tissue when the actuator mechanism is moved to the extended position.

Neuromodulation device and method of using same

System and method for obtaining a volume of influence based on non-uniform tissue conductivity data

A device and method for retaining an excess portion of a lead implanted within or on a surface of a brain of a patient is disclosed. The device comprises a burr hole ring configured to be secured to a skull of the patient and a lead retainer extending from the burr hole ring. The lead retainer is configured to store at least a section of the excess portion of the lead.

Growing community of inventors

Mayfield Heights, OH, United States of America

John D Hall