Beijing University of Technology

Australasian Drug Development Limited

John D Cullen

William Roy Jackson

Frederick C Copp

Alan L Boura

##STR1## A compound of general formula (I), wherein X=CH.sub.2, O, S or NR.sup.4, and Y=formula (II): where R.sup.1 =H, lower alkyl or an aryloxyalkyl group, wherein the aryl group is optionally substituted by alkyl, alkoxy, hydrogen, alkyl substituted by hydrogen, and n is an integer between 0 and 5, and Z=O, S or NR.sup.2 ; wherein R.sup.2 =H, lower alkyl, hydroxy, amino cyano or acyl, R.sup.3 =H, or lower alkyl, and R.sup.4 =H, lower alkyl, or lower acyl, and pharmaceutically acceptable salts thereof.

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Endeavour, Australia

John D Cullen