Battelle Memorial Institute

John D Clay

Amy M Heintz

Steven Risser

Jeffrey L Ellis

Timothy Mark Blum

Eric C Scribben

Steven M Risser

Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

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Gahanna, OH, United States of America

John D Clay