Bristol-myers Squibb Compnay

Bristol-myers Squibb

Bristol-myers

Briston-myers Squibb

John D Catt

Ronald J Mattson

Daniel J Keavy

Graham Johnson

Joseph P Yevich

Michael Frederick Parker

Katherine S Takaki

John J Wright

Dalton King

Lawrence R Marcin

Jonathan L Ditta

Mendi A Higgins

James R Epperson

Derek John Denhart

Jeffrey A Deskus

Cyclopropylindole derivatives as selective serotonin reuptake inhibitors

Novel non-dopaminergic antiischemic compounds have Formula I: ##STR1## wherein R=R.sub.1 and is independently H, C.sub.1-4 alky C.sub.1-4 alkoxy, C.sub.1-4 trihaloalkyl or halogen, or R and R.sub.1 may be taken together to form an --O(CH.sub.2).sub.m O-- (m=1 or 2);

Piperazinyl-cyclohexanes and cyclohexenes

Novel derivatives of benzopyran are provided which are useful as melatonergic agents.

Benzopyran derivatives as melatonergic agents

Novel derivatives of benzodioxa alkylene ethers are provided which are useful as melatonergic agents.

Benzodioxa alkylene ethers as melatonergic agents

Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.

Benzofuran and dihydrobenzofuran melatonergic agents

Certain indanyl piperazines are useful as melatonergic agents and can treat various CNS disorders. They are use useful in treating sleep disorders and other conditions related to circadian rhythms.

Melatonergic indanyl piperazines

Certain indanyl piperidines are useful as melatonergic agents and can treat various CNS disorders. They are useful in treating sleep disorders and other conditions related to circadian rhythms.

Indanylpiperidines as melatonergic agents

Certain aminomethyl-benzodioxanes and benzopyrans are useful serotonergic agents. They possess anxiolytic properties with few of the side effects often associated with dopaminergic agents.

Aminomethyl-benzodioxane and benzopyran serotonergic agents

Piperidinyl-substituted cyclohexanes of Formula I have anti-ischemic properties: ##STR1## wherein R=R.sub.1 and is independently H or halogen; or R and R.sub.1 may be taken together to form an --O(CH.sub.2).sub.m O-- (m=1 or 2);

Antischemic piperazinyl- and piperidinyl-cyclohexanes

Novel 3-alkoxybenzylpiperidines have melatonergic properties. They are believed useful in treating depression, jet-lag, work-shift syndrome, sleep disorders, glaucoma, some disorders associated with reproduction, cancer, immune disorders and neuroendocrine disorders.

3-alkoxybenzylpiperidine derivatives as melatonergic agents

Novel piperazinyl- and piperidinyl-cyclohexanols are useful as anxiolytic agents and have other psychotropic properties.

Piperazinyl-and piperidinyl-cyclohexanols

Novel piperazinyl- and piperidinyl-cyclohexanols of the following formula are useful as anxiolytic agents and have other psychotropic properties ##STR1##

Certain piperazinyl- and piperidinyl-substituted cyclohexanes have anti-ischemic properties.

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Southington, CT, United States of America

John D Catt