Inhale Therapeutic Systems, Inc.

Novartis Ag

Nektar Therapeutics

Other

Tekna

Bgp Products Operations Gmbh

Ph&t S.p.a.

John D Burr

Adrian Edward Smith

George S Axford

Jeffrey Wayne Etter

Carlos A Schuler

Randy Kent Hall

Charles Ray

Jack M Anthony

Herman Snyder

Jeff R Wood

Ralph F Osterhout

Robert M Platz

John A Howard

Ralph B Shamlian

Mark Glusker

Herman E Snyder

Shirley W Lyons

Fabrizio Niccolai

Jeffery W Etter

Eric R Larson

Herm Snyder

An aerosolization apparatus comprises a body having an inlet, an endpiece having an outlet, the endpiece being connectable to the body to define a chamber, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation in a manner which allows the capsule to move within the chamber. The apparatus further includes a connection mechanism to provide selective connection of the endpiece to the body, wherein a rotational force between the endpiece and the body is needed to connect or disconnect the endpiece from the body, the rotational force being applied about an axis passing through the chamber. When a user inhales, air enters into the chamber through the inlet so that the pharmaceutical formulation is aerosolized within the chamber and the aerosolized pharmaceutical formulation is delivered to the user through the outlet. The connection mechanism prevents inadvertent disconnection of the endpiece from the body.

Aerosolization apparatus with removable mouthpiece

The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

Dry powder dispersing apparatus and methods for their use

An aerosolization apparatus comprises a housing defining a chamber having an air inlet and an air outlet, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation. A puncturing member is moveable within the chamber to contact the capsule and to provide an opening in the capsule, and a feedback mechanism provides an indication, such as a tactile indication, to a user when the puncturing member has been moved to a position where it provides the opening into the capsule. When air flows through the inlet, the pharmaceutical formulation is aerosolized and the aerosolized pharmaceutical formulation is delivered through the outlet.

Aerosolization apparatus with feedback mechanism

A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.

Apparatus and methods for dispersing dry powder medicaments

Method and apparatus for dispersion of dry powder medicaments

Medicament inhaler housing

A safety utility knife includes a handle, a blade fixed to the forward end of the handle, and a retractable sheath which is received within the handle. A mechanism is provided for automatically retracting the sheath within the handle by depressing a single button at the rear of the handle.

Knife with retractable sheath

An improved regulator intended primarily for use as the essential component of a SCUBA system and being a single hose, two stage regulator incorporating a novel valve subassembly in the second stage in the form of a unique main diaphragm valve and a pilot valve assembly.

Pilot regulator

Growing community of inventors

Redwood City, CA, United States of America

John D Burr