The Procter Gamble Company

John Crist Bierman

Stevan David Jones

John Erich Oblong

Kevin John Mills

Supriya Punyani Bareja

Leo Timothy Laughlin

Michael Koganov

Leo Timothy Laughlin, Ii

Tomohiro Hakozaki

Larry Richard Robinson

Wenzhu Zhao

Cheri Lynn Swanson

Jiazhen Wang

Jason Michael Price

Kurt Glen Kronholm

Leo Timothy Ii Laughlin

Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a cell, a cell culture, or bulk cells with the test agent, wherein the cell, the cell culture, or the bulk cells comprise ADR&#x3b2;1 receptors, and determining based on the binding interaction of the test agent with the ADR&#x3b2;1 receptors whether the test agent is an effective ADR&#x3b2;1 receptor antagonist suitable for modifying the appearance of pigmented skin, wherein a test agent is considered to be an effective ADR&#x3b2;1 receptor antagonist when it defines a half maximal inhibitory concentration of less than about 1000 ppm.

Screening methods of modulating adrenergic receptor gene expressions implicated in melanogenesis

Cosmetic compositions for alleviating the signs of photoaged skin containing a substituted azole. Methods for alleviating the signs of photoaged skin that include applying a cosmetic composition comprising substituted azole to a target UV-exposed skin surface. The substituted azole compound present in the cosmetic composition may be 1-phenylimidazole, 4-phenylimidazole or a combination thereof. An effective amount of the cosmetic composition is applied to the target skin surface for a period of time sufficient to alleviate at least one sign of photoaging.

Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin

Methods of improving the appearance of aging skin that include applying a cosmetic composition to a target skin surface having one or more signs of aging. The cosmetic composition includes a substituted azole. In some instances, the substituted azole compound is 1-phenylimidazole, 4-phenylimidazole, or combinations thereof. An effective amount of the cosmetic composition is applied for a period of time sufficient to improve the appearance of at least one sign of aging skin.

Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin

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Cincinnati, OH, United States of America

John Crist Bierman