Celltech R&d Limited

Celltech Therapeutics Limited

Ucb Pharma, S.a.

John Clifford Head

John Robert Porter

Graham John Warrellow

Sarah Catherine Archibald

Rikki Peter Alexander

Barry John Langham

Julien Alistair Brown

Janeen Marsha Linsley

James Andrew Johnson

Stephen Brand

Stuart Bailey

Brian Woodside Hutchinson

Timothy John Norman

Andrew James Ratcliffe

Ewan C Boyd

Catherine McKay

James Thomas Reuberson

Phenylalanine enamide derivatives of formula (1) are described: wherein in which R is a carboxylic acid (&#x2014;COH) or a derivative or biostere thereof; The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

Phenylalanine enamide derivatives

Phenylalanine enamide derivatives of formula (1) are described:   The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

Alkanoic acid derivatives of formula (1) are described:Ar(Alk)LArCH(R)C(R)(R)R&#x2003;&#x2003;(1) The compounds are able to inhibit the binding of &#x3b1;4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.

&#x3b2;-alanine derivates

Phenylalanine derivatives of formula (1) are described:wherein The compounds are able to inhibit the binding of a 4 integrins to their ligands and are of use in the prophylaxis and treatment of diseases or disorders involving inflammation.

Phenylalanine derivatives

Phenylalanine enamide derivatives of formula (1) are described:wherein The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

Enamine derivatives

Squaric acid derivatives

Bicyclic enamide derivatives

3-substituted 2,7-naphthyridin-1-yl derivatives

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Maidenhead, United Kingdom

John Clifford Head