Lilly Industries, Inc.

John Wyeth Brother, Limited

Eli Lilly and Company

John Christopher Saunders

William R Williamson

John T Boyle

John Leheup Archibald

William J Ross

Delme Evans

William B Jamieson

Roger G Harrison

John Arnott Boyle

Acylamino tetrazolyl compounds having anti-allergic activity, methods of making the compounds and pharmaceutical formulations containing the compounds.

Acylamino derivatives

Acylamino pyrazolyl compounds of the formula: ##STR1## wherein Ar represents an optionally substituted pyrazolyl group, the acylamino group --NR.sup.1 COR.sup.2 being attached to a carbon atom of the pyrazolyl ring, which have anti-allergic activity, methods of making the compounds and pharmaceutical formulations containing the compounds.

Acylaminopyrazoles

o-Hydroxybenzophenones and derivatives thereof are described together with a process for their production. The compounds have anti-allergy activity and are characterized by the presence of an alkyl substituent on the hydroxyphenyl ring.

Ketone derivatives

Novel benzophenone derivatives having anti-allergy activity, and pharmaceutical formulations and methods of treatment utilizing benzophenone derivatives.

Benzophenone derivatives

Novel heteroaryl ketone derivatives, specifically a class of phenyl heteroaryl methanone derivatives, having anti-allergy activity, pharmaceutical formulations containing diphenylmethane derivatives and methods of treatment utilizing such derivatives.

Heteroaryl ketone derivatives

An aryl sulphur compound of formula (I) : ##STR1## where R.sup.1 is C.sub.1-4 alkyl; Ar is a phenyl group optionally substituted by halogen or C.sub.1-4 alkyl and wherein Z is S or SO, having antiallergy activity.

Aryl sulphur compounds as antiasthmatics

1,2,3-triazoles and 1,2,4-triazoles having an N-substituted acylamino substituent are prepared by alkylating N-unsubstituted acylamino triazoles or acylating N-substituted amino triazoles. The N-substituted acylamino triazoles are useful as anti-allergy drugs. Pharmaceutical formulations containing acylamino triazoles and a method of treating allergic conditions utilizing such compounds are provided.

Acylamino triazoles as antiasthmatic agents

Phthalimidopiperidines of the formula ##STR1## are described where R.sub.1 is hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, phenyl(lower)alkyl, pyridyl(lower)alkyl, furyl(lower)alkyl or thienyl(lower)alkyl and R.sub.2 and R.sub.3 are hydrogen or various substituents. The compounds are useful pharmaceutically, particularly as anti-convulsants, and also in some cases as anti-arrhythmic agents and anti-inflammatory agents, and in some cases useful as intermediates for the preparation of 4-aminoquinoline derivatives having anti-malarial activity.

Phthalimidopiperidines and anti-convulsant compositions thereof

3-(7-Halo-4-quinolyl)-N-[di(loweralkyl)amino(lower alkyl)]-N-(lower alkyl)benzamides and 4-(7-halo-4-quinolyl)-N-[di(lower alkyl)amino(loweralkyl)]-N-(lower alkyl)benzamides and their pharmaceutically acceptable acid addition salts exhibit interesting anti-inflammatory activity. They also exhibit anti-malarial activity and anti-hypertensive activity.

(4-Quinolylamino)benzamides

The disclosure describes new 4-aminoquinoline derivatives of general formula ##SPC1## And their acid addition salts, where X is a halogen atom or a trifluoromethyl group, Z is a hydrogen atom or a defined substituent, R is group of the formula

O-(4-Quinolylamino)benzamides

This invention relates to compounds having the formula: ##SPC1## And the pharmaceutically acceptable acid addition salts thereof, wherein R represents a phenyl or substituted phenyl radical in which said substituent is halogen, lower alkyl, lower alkoxy, nitro or trihalo lower alkyl; A represents a lower alkylene radical; and R.sup.1 and R.sup.2 independently represents hydrogen or lower alkyl; or R.sup.1 and R.sup.2 together with the nitrogen to which they are attached represent a heterocyclic ring selected from pyrrolidino, piperidino or morpholino; which inhibit blood platelet aggregation.

1 (H)-1,2,4-triazole derivatives

3-Phenyl substituted 1,2-benzisoxazole acetic and propionic acid derivatives with anti-inflammatory activity.

Growing community of inventors

Maidenhead, United Kingdom

John Christopher Saunders