Novartis Ag

Novartis Pharma Gmbh

John Christopher Phelan

Michael Hugh Quinn

Robert Carey Tucker

Sandra Corti

Joshua Andrew Wallach

Marcia Kay Ash

Yongxing Qiu

Lynn Cook Winterton

Rafael Victor Andino

Joseph Michael Lindacher

Angelika Maria Domschke

Robert A Scott

Courtney Flem Morgan

Allen Douglas Gilliard

Cornelius Daniel Niculas

Corneliu Daniel Niculas

Lawrence Chapoy

Tomasz Jankiewicz

The present invention provides methods for lathing at room temperature a silicone hydrogel material, in particular silicone hydrogel material having a high oxygen permeability and made of a polymerizable composition containing a relative large amount of oxyperm component, into contact lenses.

Method for lathing silicone hydrogel lenses

The present invention provides inks and methods for making colored silicone hydrogel contact lenses. The ink of the invention comprises an actinically-curable binder copolymer comprising fluorine-containing segments and is characterized by having capability to be cured actinically or thermally to form a colored film on a molding surface of a mold or a silicone hydrogel contact lens and by having an increased durability in a solvated state in a silicone-hydrogel lens formulation in relation to a control colored film obtained from a control ink including an actinically-curable fluorine-free binder copolymer. The invention also provides methods for making colored silicone hydrogel contact lenses based on print-on-mold processes for producing colored contact lenses.

Actinically curable silicone hydrogel copolymers and uses thereof

The present invention provides an actinically or thermally curable ink for making colored silicone hydrogel contact lenses. The ink of the invention comprises at least one colorant, a solvent and a binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromer. The ink of the invention is characterized by having capability to be cured actinically or thermally to form a colored coat on a silicone hydrogel contact lens, wherein the colored coat has good adhesion to the silicone hydrogel contact lens without being covalently attached to the lens material of the contact lens. The invention also provides methods for making colored silicone hydrogel contact lenses.

Curable colored inks for making colored silicone hydrogel lenses

The present invention provides a method and a formulation for consistently producing a silicone hydrogel material having relatively high oxygen permeability, relatively high ion permeability, and low modulus, and contact lenses prepared from a formulation of the invention or made of a silicone hydrogel material of the invention.

Method for preparing silicone hydrogels

The invention provide a new class of silicone-containing prepolymers containing ethylenically unsaturated groups and latent UV-activated free radical generating moieties. This class of silicone-containing prepolymer is capable of being actinically crosslinked in the presence of one or more hydrophilic vinylic monomers to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and a vinylic monomer having a latent UV-activated free radical generating moiety.

Silicone hydrogel materials with chemically bound wetting agents

The invention provides an actinically-crosslinkable linear polysiloxane copolymer. The actinically-crosslinkable polysiloxane copolymer can be used to prepare a silicone hydrogel contact lens having a hydrophilic surface without post-curing surface treatment. The invention is also related to a silicone hydrogel contact lens obtained from a lens-forming material including an actinically-crosslinkable polysiloxane copolymer of the invention and to a method for making an actinically-crosslinkable polysiloxane copolymer of the invention. In addition, the invention provides a non-crosslinkable linear polysiloxane copolymer capable of being used as a internal wetting agent which can render the surface of a silicone hydrogel contact lens hydrophilic.

Polysiloxane copolymers with terminal hydrophilic polymer chains

The present invention provides a polymerizable material for making a polymeric article, the polymerizable material comprising: a water-soluble polyvinyl alcohol having crosslinkable groups; and a modifier in an amount sufficient to improve one or more physical properties of a polymeric article made from the polymerizable material, wherein the one or more physical properties are selected from the group consisting of stress at break (N/mm), percentage of elongation at break, toughness or energy to break (N&#xb7;mm), and susceptibility to fracture. The modifier is selected from the group consisting of nanoparticles having a hydrophilic surface, a copolymer having hydrophobic groups or units for imparting at least one desired physical property to said ophthalmic device and hydrophilic groups or units in an amount sufficient to render the copolymer miscible with the polyvinyl alcohol, and mixtures thereof. In addition, the present invention provides a polymeric article obtained by polymerization of a polymerizable material of the invention and also a method for modifying one or more physical properties of a hydrogel article obtained from the polymerization of a crosslinkable polymer.

Polymerizable materials

The present invention provides silicone hydrogel materials having relatively high oxygen permeability and a relatively low modulus. The relatively-low modulus is achieved by adding a chain transfer agent into a polymerizable fluid composition in an amount sufficient to provide to the resultant silicone hydrogel material with a reduced modulus. In addition, the invention provides silicone hydrogel contact lenses comprising a silicone hydrogel material of the invention, a method for making a silicone hydrogel material of the invention, and a method for making a silicone hydrogel contact lens of the invention.

Silicone hydrogels

The present invention provides novels inks and methods for making a colored polymeric substrates, preferably a contact lens. In the inventive method at least a portion of a surface of a lens is coated with a color coat comprising at least one colorant, and a binder polymer obtained by copolymerizing a first monomer being ethylenically unsaturated and having a latent crosslinkable pendent group; and a second monomer having an ethylenically unsaturated double bond copolymerizable with the first monomer. The lens is then subjected to conditions that cause the color coat to adhere to the lens.

Colored printing ink for contact lenses

An aqueous ink comprising containing a colorant and a radiation-curable oligomer or polymer containing H-active groups bonded to the oligomer or polymer backbone, some or all of whose hydrogen atoms have been substituted by radicals of a N-hydroxyalkyl (meth)acrylamide. Methods for printing the inventive inks upon medical devices, such as contact lenses, are also disclosed.

Biocompatible inks, preparation, and uses thereof

The present invention provides a radiation-curable prepolymer. The radiation-curable prepolymer of the invention is prepared by reacting an isocyanate-capped polyurethane with an ethylenically unsaturated amine or an ethylenically unsaturated monohydroxy compound or a mixture thereof, wherein the isocyanate-capped polyurethane is a copolymerization production of: (a) at least one polyalkylene glycol; (b) at least one branching agent having at least three hydroxy groups; and (c) at least one di- or polyisocyanate. The radiation-curable prepolymer of the invention can find use in economically producing contact lenses which have durable, highly elastic soft contact lenses with desired physical properties. In addition, the present invention provides method for making a radiation-curable prepolymer of the invention and for making a medical device, preferably an ophthalmic device, more preferably a contact lens.

Radiation-curable prepolymers

The present invention generally relates to a method for making made-to-order (MTO) or customized silicone hydrogel lenses which have printed images on and/or below lens surfaces. A preferred method of the invention comprises printing and curing an ink on the molding surface of a mold for molding a single-side molded lens blank, producing the single-sided molded lens blank having a molded surface corresponding to one of the anterior and posterior surfaces of the lens to be produced and having an image embedded in the lens body and below lens surface, and directly lathing the lens blank on the side opposite to the molded surface to form the other lens surface. Colored silicone hydrogel lenses produced according to the invention will be useful as daily wear lenses and extended wear lenses. The lenses will allow alteration or enhancement of a patient's eye color.

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Gurnee, IL, United States of America

John Christopher Phelan