Medtronic, Inc.

Cvrx, Inc.

John Charles Stroebel

Paul A Belk

Thomas J Mullen

David Arthur Casavant

H Toby Markowitz

Robert A Betzold

Todd Jon Sheldon

Karen J Kleckner

Catherine R Condie

Bart Carey

Morgan Beeson

Al Crouse

Yifei Yao

Cliff Rockwell

Robert L Davidson

Robert S Kieval

Eric G Lovett

Paul J Huelskamp

William J Combs

John D Wahlstrand

Forrest C M Pape

Russell E Anderson

James H Ericksen

Douglas A Peterson

Daniel J Baxter

Nadim Yared

Steven R Hornberger

Daniel J Greeninger

Steve Check

David Jerome Peichel

Purvee P Parikh

Robert W Stadler

Jeffrey M Gillberg

Troy Edward Jackson

D Curtis Deno

Michael F Hess

John C Rueter

Javaid Masoud

Michael O Sweeney

Todd A Kallmyer

Jeffrey David Wilkinson

Kevin K Walsh

Michael B Shelton

Carleen J Juran

James E Willenbring

Robert A Neumann

William J Plombon

Ren Zhou

Mark A Stockburger

Robert A Gabler

Tho V Huynh

Pierce Vatterott

Chris T House

Xander Evers

Harry A Strandquist

Kristin Yakimow

Purvee Praduman Parikh

Robert A Betzhold

Display screen or a portion thereof with graphical user interface

A pacing mode is provided, in one embodiment, that permits missed or skipped ventricular beats. The mode monitors a full cardiac cycle (A-A interval) for the presence of intrinsic ventricular activity. If ventricular activity is present, a flag is set that is valid for the next cardiac cycle. At the beginning of the next cardiac cycle, the device determines if the flag is present. So long as the flag is present, the device will not deliver a ventricular pacing pulse in that cycle, even if there is no intrinsic ventricular activity. If there is no flag present at the start of a given cardiac cycle, a ventricular pacing pulse is delivered and this ventricular activity sets a flag for the subsequent cardiac cycle.

Fully inhibited dual chamber pacing mode

A preferred atrial-based pacing method and apparatus is provided using an intelligent cardiac pacing system to having the ability to continue atrial-based pacing as long as relatively reliable AV conduction is present. In the event that such relatively reliable AV conduction is not present, mode switching to a DDD/R or a DDI/R pacing mode while continually biased to mode switch back to atrial-based pacing. The standard or relatively reliable AV conduction may be changed either automatically or manually. This increases pacing that utilizes natural AV conduction however possible so as to gain all the benefits of cardiac contractile properties resulting therefrom, while tolerating the occasional missed ventricular depolarization (i.e., non-conducted P-wave). In the event where relatively reliable AV conduction is not present, the pacing mode is switched to a DDD/R mode while detecting a return of the relatively reliable AV conduction (and resulting mode switch to preferred atrial based pacing).

Preferred ADI/R: a permanent pacing mode to eliminate ventricular pacing while maintaining backup support

The invention relates to medical devices such as pacemakers, pulse generators, cardioverter-defibrillators and the like and more particularly relates to modular and reconfigurable medical system platforms and methods of designing, testing, controlling and implementing diverse therapies, diagnostics, physiologic sensors and related instrumentation using said medical system platforms. Methods, systems and devices provide a new design platform for implantable and external medical devices such as pacemakers, defibrillators, neurostimulators, heart monitors, etc. A real-time, highly flexible system of software and hardware modules enables both prototypes and products to respond to patient and customer needs with greater design and manufacturing efficiency. Certain embodiments integrate a general-purpose processor with interface circuitry to provide a standard platform for implementing new and conventional therapies with software models rather than custom circuitry. The platform described may be used as a simulation environment, development and test platform and/or may be used as architecture for building new medical devices.

Software configurable medical device platform and associated methods

The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or 'CRT').

LV threshold measurement and capture management

A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter, obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter, calculating vascular impedance based on the measurement signal and the resultant signal, and calculating a physiological parameter based on the vascular impedance. In some embodiments, the physiological parameter is utilized to modify a therapy signal controlling therapy delivered to the patient.

Measurement of patient physiological parameters

Pacing parameters are provided to address cross talk and intrinsic ventricular events occurring within a predefined blanking period following an atrial event. The parameters are used in conjunction with protocol for minimizing or reducing ventricular pacing, wherein ignoring intrinsic ventricular events during the blanking period might otherwise affect the performance of the protocol.

Ventricular event filtering for an implantable medical device

An ADI/R mode is implemented using an intelligent pacing system to continually monitor ventricular response. This ensures AV conduction whenever possible so as to gain all the benefits of cardiac contractile properties resulting from native R-waves. In the event where AV conduction is blocked, the pacing mode is switched to a DDD/R mode to ensure a paced R-wave. Thereafter, subsequent to a completed interval of a p-wave, ADI/R pacing resumes to monitor ventricular response.

A bus system is provided for implantable medical devices. The bus system provides for flexible and reliable communication between subsystems in an implantable medical device. The bus system facilitates a wide variety of communications between various subsystems. These various subsystems can include one or more sensing devices, processors, data storage devices, patient alert devices, power management devices, signal processing and other devices implemented to perform a variety of different functions.

Implantable medical device bus system and method

Growing community of inventors

Blaine, MN, United States of America

John Charles Stroebel