Micromass UK Limited

Waters Technologies Corporation

John Charles Gebler

Weibin Chen

Jeffery Mark Brown

Asish B Chakraborty

Martin Gilar

Edouard S P Bouvier

James Ian Langridge

Jeff Brown

Bruce J Compton

Emmanuelle Claude

Peter Jeng Jong Lee

Dominic Gostick

Ying-Qing Yu

Jeffrey Mark Brown

Jeffrey W Finch

Edouard S Bouvier

Peter Jeng-Jong Lee

Ying Qing Yu

Elizabeth K Kane

Elizabeth K Brown

Fang Xia

Santiago Vazquez

Peter J Lee

Edouard SP Bouvier

A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.

Method of charge reduction of electron transfer dissociation product ions

The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.

Destructible surfactants and uses thereof

A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cellby reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.

A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit (), and flowing a solvent having a time-varying composition through the conduit (). An apparatus for extracting at least one target compound from a sample includes a chromatography module, a mass-spectrometry module in fluid communication with the chromatography module to receive a portion of an eluent from the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.

Apparatus and methods for mass-spectrometric directed purification of biopolymers

Disclosed herein is a sample preparation plate used to prepare a sample for mass spectrometry. In particular, a sample plate used to concentrate a sample as well as remove contaminants from the sample while providing easy manipulation of small liquid droplets on a surface with minimal sample loss.

Sample preparation plate for mass spectrometry

A MALDI sample plateis disclosed which comprises a metallic substratehaving a circular groove or moat. A hydrophobic polytetrafluoroethylene layeris applied to the substrateand a central portionof the substrateis laser etched which roughens the surface of the substrate. A thin polystyrene layer is then applied to the polytetrafluoroethylene layerand the central portion

MALDI sample plate

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Hopkinton, MA, United States of America

John Charles Gebler