University of Michigan

Other

Wayne State University

Chimerix, Inc.

US Government As Represented by the Secretary of the Army

Smithkline Beecham Corporation

Wake Forest University

Burroughs Wellcome Co.

Glaxo Wellcome Inc.

John Charles Drach

Leroy B Townsend

Jiri Zemlicka

Roy Wendell Ware

Ernest Randall Lanier, Jr

Andrew Louis McIver

John Henry Bougher, Iii

Ramamurty V S Changalvala

Dean Wallace Selleseth

Bradley David Robertson

Phiroze Behram Sethna

Louis S Kucera

Aaron Leigh Downey

Roger G Ptak

Yao-Ling Qiu

Susan Mary Daluge

Stanley Dawes Chamberlain

Xinchao Chen

Shaoman Zhou

George Andrew Freeman

Sandra H Smith

Michael Tolar Martin

George Walter Koszalka

Marc W Andersen

Daniel L Klayman

David Norman Deaton

Jeffrey H Tidwell

Gordon L Flynn

George A Freeman

Charles Shipman, Jr

Frank Leslie Boyd, Jr

Thomas E Renau

Steven S Good

Joseph H Chan

Steven H Krawczyk

John Henry Iii Bougher

The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rand A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.

Pyrrolopyrimidine nucleosides and analogs thereof

The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rand A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II. 

Compounds which are active against viruses have the following Formulas: 

2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents

Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino-6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.

2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and -pyrimidines as antiviral agents

The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.

Indole antiviral compositions and methods

2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrimidines as antiviral agents

2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents

Compounds which are active against viruses have the following Formulas:wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of 6-aminopurine (adenine), 2,6-diaminopurine, 2-amino-6-azidopurine, 2-amino-6-cyclopropylaminopurine, 6-hydroxypurine (hypoxanthine), 2-amino-6-halo substituted purines, 2-amino-6-alkoxy substituted purines, 2-amino-6-hydroxypurine (guanine), 3-deazapurines, 7-deaza-purines, 8-azapurines, cytosine, 5-halo substituted cytosines, 5-alkyl substituted cytosines, thymine, uracil and 6-azapyrimidines; X is O; and, Rand Rare alkyl or aryl groups. The compounds of the present invention also include the R- and S-enantiomers of the above compounds. The RX and/or RX can also be amino acid residues with X as NH.

2-hydroxymethylcyclopropylidene methylpurines and -pyrimidines as antiviral agents

2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents

Growing community of inventors

Ann Arbor, MI, United States of America

John Charles Drach