University of Bristol

Gloucestershire Hospitals Nhs Foundation Trust

Renishaw Plc

University of Exeter

Rolls-royce Corporation

John Charles Clifford Day

James Kell

Nicholas Stone

Robert Bennett

Andrew Mark Woolfrey

Alastair Poole

Angus Bewick

Joanne Hutchings

Graham Mark Meaden

A probe comprising a body portion and a tip portion. The body portion comprises: a first mounting portion comprising a plurality of first carriers, each first carrier being arranged to support an elongate first waveguide, the first carriers being disposed in an equiangular arrangement around a longitudinal axis of the body portion; a plurality of first waveguides, each first waveguide being supported in a respective one of the plurality of first carriers; and a body end fitting at which first ends of the first waveguides are supported in the equiangular arrangement around the longitudinal axis of the body portion such that the first waveguides can transmit electromagnetic radiation signals from an energy source to the body end fitting and/or transmit electromagnetic radiation signals from the body end fitting to a receiver. The tip portion comprises: a second mounting portion comprising a plurality of second carriers, each second carrier being arranged to support an elongate second waveguides, the second carriers being disposed in the equiangular arrangement around a longitudinal axis of the tip portion; a plurality of second waveguides, each second waveguides being supported in a respective one of the plurality of second carriers; and a tip end fitting at which first ends of the second waveguides are supported in the equiangular arrangement around the longitudinal axis of the tip portion; and an elongate conduit for piercing human tissue.

Probe for optical spectroscopy

A probe, such as a spectroscopic probe, for enabling a fluid or tissue sample to be tested in situ. The probe includes a conduit, such as a hypodermic needle, that can be inserted into a test subject and a wave coupling arranged to direct electromagnetic radiation, such as light, from an energy source to the sample and/or from the sample to a receiver for analysis. The receiver may comprise a Raman spectroscope. The probe may include a carriage that can be used to move at least some of the optical coupling towards and away from the insertion tip of the conduit. The probe may include a pressure modifier that can be used to draw fluid into or expel fluid from the conduit.

Probe with a removable tip

A microfluidics analysis system with a microfluidics cell and a microscope. The microscope has an objective lens arranged to collect light from a field of view including a portion of the microfluidics cell; a second lens; and an actuator arranged to translate the objective lens relative to the microfluidics cell to change a position of the field of view between multiple positions. The actuator is arranged to translate the objective lens relative to the microfluidics cell without moving the second lens relative to the microfluidics cell. The second lens is arranged to receive the light collected by the objective lens for the multiple positions of the field of view without moving relative to the microfluidics cell.

Microfluidics analysis system

An optical device includes a first sub-assembly having an input lens for collimating illuminating light and having an optical axis. The first sub-assembly also has an output lens for focusing collimated light received from a sample, the output lens having an optical axis which is offset and substantially parallel with the optical axis of the input lens, and further includes a first support piece which houses and supports the input lens and the output lens. The optical device also includes a second sub-assembly having an input filter for filtering the collimated illuminating light, an output filter for filtering the collimated light received from the sample, and a second support piece which houses and supports the input filter and the output filter. The first and second support pieces are joined together by a liquid-tight joint.

Optical device

A spectroscopy method in which a sample is scanned without moving the sample. Light from the sampleis collected by a lensand analyzed at a spectrum analyzerbefore being focused onto a photodetector. Light from the focal point of the lensis brought to a tight focus on the photodetectorwhilst light from in front of or behind the focal point comes to a more diffuse focus. Light from the pixels on the photodetectorcorresponding to the focal point of the lensis processed, whilst light from pixels outside this region is ignored, thus forming a 'virtual slit'. The sampleis scanned in a vertical direction by moving the 'virtual slit' up and down, by changing the designated rows of pixels from which data is analyzed. The sample is scanned in a horizontal direction by moving a vertical slitin the light path in a horizontal direction.

Spectroscopy apparatus and method

An electron microscopeis adapted to enable spectroscopic analysis of a sample. A parabolic mirrorhas a central aperturethrough which the electron beam can pass. The mirrorfocuses laser illumination from a transverse optical pathonto the sample, and collects Raman and/or other scattered light, passing it back to an optical system. The mirroris retractable (within the vacuum of the electron microscope) by a sliding arm assembly

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Bristol, United Kingdom

John Charles Clifford Day