Elizabeth Arden Company, Division of Conopco, Inc.

Quest International B.v.

Unichem Chemie Bv

John Casey

Anthony V Rawlings

Alasdair Robin Macrae

Alfons L Peters

John Anthony Bosley

John Turner Mitchell

Peter C Harries

Peter S Cheetham

Rudolf M Veloo

Katherine A Maume

Gary MyCock

Della Hyliands

Process for the esterification of carboxylic acids with tertiary

An efficient method of producing phytosphingosine-containing ceramide one comprising: (a) obtaining a phytosphingosine base from tetraacetylphytosphingosine (TAPS) by a deacetylation reaction wherein the TAPS is produced by fermentation of cells of the F-60-10 mating type strain of Hansenula ciferrii using a fed-batch mode and a non-fermentable carbon source; and (b) coupling together the phytosphingosine base and a fatty acid/.omega.-hydroxy fatty acid component wherein the .omega.-hydroxy fatty acid component is prepared by a process which includes Kolbe synthesis.

Method of synthesizing lipids and cosmetic composition comprising them

The invention concerns a process for preparing tetraacetylphytospingosine (TAPS) using F-60-10 mating type strain of Pichia ciferrii. Such strain is subjected to mutagenesis and the high TAPS producing strains are selected by a special procedure. These strains are grown in a fed batch mode on a non-fermentative carbon source at a temperature above 26.degree. C and the TAPS collected from the fermentation medium. Glycerol is a preferred carbon source and preferably L-serine is added to the culture medium.

Preparation of phytosphingosine derivative

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Wellingborough, United Kingdom

John Casey