Zogenix, Inc.

University of Greenwich

John Carlton Mitchell

Gregor John McLennan Anderson

Simon Clifford Wainwright Richardson

Paul Douglas Remane Dyer

The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs). Hybrid ASOs, part single-stranded and part double-stranded, are provided, hybridizing to form a double-stranded region that can non-covalently bond to nucleic-acid-binding protein regions. In this way, ASO::protein complexes may be produced that facilitate delivery of antisense DNA into target cells. Such complexes may be used to down-regulate gene expression in cells.

Antisense oligonucleotide compositions

A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively moveable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.

Casing

A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively movable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.

A casing () for an injection device () of the type having a safety device which prevents operation of the device (), incorporating an actuator means () by which the safety means of the device () can be actuated to allow operation of the device (). Also a casing () for a medicament container having an opening closed prior to use by a break-off tip (), having relatively moveable first and second casing parts (), which on relative movement apply a breaking force to the break-off tip (). A preferred embodiment includes both such features.

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London, United Kingdom

John Carlton Mitchell