Los Alamos National Security, LLC

John C Mosher

Michelle A Espy

Robert Henry Kraus, Jr

Petr Lvovich Volegov

Andrei Nikolaevich Matlashov

Using resonant interactions to directly and tomographically image neural activity in the human brain using magnetic resonance imaging (MRI) techniques at ultra-low field (ULF), the present inventors have established an approach that is sensitive to magnetic field distributions local to the spin population in cortex at the Larmor frequency of the measurement field. Because the Larmor frequency can be readily manipulated (through varying B), one can also envision using ULF-DNI to image the frequency distribution of the local fields in cortex. Such information, taken together with simultaneous acquisition of MEG and ULF-NMR signals, enables non-invasive exploration of the correlation between local fields induced by neural activity in cortex and more 'distant' measures of brain activity such as MEG and EEG.

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Los Alamos, NM, United States of America

John C Mosher