Smithkline Beecham Corporation

Smithkline Beckman Corporation

John C Lee

Jerry Leroy Adams

Timothy Francis Gallagher

Paul E Bender

John Richard White

Don Edgar Griswold

Nabil Hanna

Jeffrey Charles Boehm

Peter R Young

Peter William Sheldrake

Joseph Sisko

Peter C McDonnell

James E Strickler

Dean E McNulty

John Richard Heys

Zhi-Qiang Peng

David W Green

Ravi Shanker Garigipati

Alison Mary Badger

Klaus M Esser

Philip L Simon

Ravishanker Garigipati

Bartholomew J Votta

Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.

Compounds

This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.

Antibodies produced against cytokine suppressive anti-inflammatory drug binding proteins

Novel 1, 4, 5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.

The present invention is to a novel process for the preparation of a compound of the formula: ##STR1## wherein p is 0, or 2;

Process of making tosylbenzyl formamide derivatives

The present invention is directed to the novel intermediate compounds of the formula: ##STR1## wherein, interalia, R.sub.4 is a substituted phenyl or an optionally substituted napthyl derivative.

Amide compounds

Polynucleotides encoding cytokine suppressive anti-inflammatory drug

Pyrimidinyl imidazoles

Cytokine suppressive anit-inflammatory drug binding proteins

Imidazole derivatives and their use as cytokine inhibitors

Pyridyl imidazoles

Inhibition of interleukin-1 and tumor necrosis factor production by

A method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a diaryl-substituted imidazole fused to a thiazole pyrrolidine, thiazide or piperidine ring to such animal.

Inhibition of interleukin-1 production by monocytes and/or macrophages

A method of inhibiting the production of interleukin-1 by monocytes in a human in need thereof which comprises administering to such human an effective interleukin-1 production inhibiting amount of a 4,5-diaryl-2(substituted)imidazole.

Inhibition of interleukin-1 by monocytes and/or macrophages

A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such human an effective interleukin-1 production inhibiting amount of a 2-2'-[1,3-propan-2-onediyl-bis(thio)]bis-1H-imidazole or a pharmaceutically acceptable salt thereof.

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Radnor, PA, United States of America

John C Lee