Alcon Laboratories, Inc.

Other

University of Southern Mississippi

John C Lang

Steven Thomas Charles

Lon J Mathias

Robert Yeats Lochhead

Mark E Hammer

Paul J Missel

Bhagwati P Kabra

Rajni Jani

Jamieson C Keister

Manoj L Maniar

Dimitri J Stancioff

R Scott Hunter

In vivo polymerizable intraocular lens compositions which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends. The compositions are preferably cured by UV photoinitiation and are useful in repairing torn or detached retinal tissue or forming intraocular lenses in situ.

In vivo polymerizable ophthalmic compositions and methods of using

Coatings for surgical instruments which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends.

Articles coated with in vivo polymerizable ophthalmic compositions

Fluoroalkyl hydrocarbons as vehicles for pharmaceutical drugs are disclosed. These vehicles are particularly well-suited for delivering drugs which are insoluble in water or chemically unstable in aqueous media. Pharmaceutical solution compositions based on these vehicles have long shelf lives and provide improved drug bioavailability. In addition, the pharmaceutical compositions of the present invention are nonaqueous, and therefore do not require preservatives or tonicity agents. The invention is particularly useful in the field of ophthalmology.

Fluoroalkyl hydrocarbons for administering water insoluble or unstable

Ophthalmic compositions containing biocompatible, bioadhesive polymerizable amphipathic mesophase materials useful for repairing retinal tissue tears or retinal detachments are disclosed. In one embodiment, the polymerizable materials, which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends, are polymerized in vivo to provide effective, long-lasting repair of torn, ruptured or detached retinal tissue. Ophthalmic applications of these materials are not limited to retinal repair.

In vivo polymerizable ophthalmic compositions

Drug delivery vehicles which reversibly increase in either loss modulus or storage modulus, or both, upon contact with the eye, skin, mucous membrane or body cavity are disclosed. The vehicles contain one or more nonionic substituted cellulose ethers and do not require a charged surfactant or a pH-sensitive polymer for such increase in loss modulus or storage modulus, or both, upon administration. In one embodiment, the vehicles gel upon instillation in the eye.

Thermally-gelling drug delivery vehicles containing cellulose ethers

Topical ophthalmic compositions of carrageenans which are administrable as a drop but which become more viscous or gel upon instillation in the eye are disclosed. Methods for use of the compositions as topical ophthalmic vehicles for pharmaceutically active agents, and alone as lubricants or tear supplements, are also disclosed.

Use of carrageenans in topical ophthalmic compositions

Ophthalmic compositions comprising combinations of gelling polysaccharides and finely-divided drug carrier substrates which become relatively more viscous on contact with the eye are disclosed. These ophthalmic compositions are both comfortable and long-lasting Ophthalmic compositions further comprising a pharmaceutically active drug are also disclosed, as are methods of use.

Use of combinations gelling polysaccharides and finely divided drug

A fluid filtering assembly has a manifold connectable to a line carrying fluid and a filter cartridge releasably connected to the manifold. The manifold has a pair of pockets that accommodate fluid inlet and outlet tubular members on the filter cartridge. Seals associated with the pockets and tubular members retain the fluid to the manifold and filter cartridge. A releasable connector holds cartridge in assembled relation with the manifold.

Manifold and disposable filter assembly

A refuse receptacle with refuse bags being supplied from the bottom thereof from a replaceable package of said bags. The container has a general usefulness but is particularly adapted for use in counting and disposing of sponges and other articles during a surgical procedure.

Growing community of inventors

Arlington, TX, United States of America

John C Lang