Eastman Chemical Company

Eastman-kodak Company

Other

Polygen Holding Corporation

John C Hubbs

Charles H Foster

Marti N Harrison

Cyril Y Bowers

Wayne Livingston Cody

Frank A Momany

Charles Michael Buchanan

Neil Warren Boaz

Robert J Clemens

Ching H Chang

Alan W White

Theresa Sims Barnette

Ronald H Birkhahn

Nick Allen Collins

Robert M Gardner

Charles A McCombs

Ruairi Seosamh O'Meadhra

Steven Thomas Perri

Chester Wayne Sink

Bhaskar Krishna Arumugam

Steven C Gedon

John Thorton Maddox

Douglas C Hoffman

David Carl Attride

William D Nottingham

Mark Robert Shelton

George William Tindall

David Chris Spencer

James Charles Ciula

Thomas Nabih

Stephen W Parker

Poly(3-cyclopropyl-3-hydroxypropionates) (I) which are useful for the preparation of vinylcyclopropane and cyclopropylacetylene are disclosed. Methods for the preparation of a variety of intermediates obtained from (I) such as 3-cyclopropyl-3-hydroxypropionic acid and esters and salts thereof, 3-cyclopropylacrylic acids and vinylcyclopropane also are disclosed.

Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof

Process for the recovery of organic acids from aqueous solutions

Poly(3-cyclopropyl-3-hydroxypropionates) (I) which are useful for the preparation of vinylcyclopropane and cyclopropylacetylene are disclosed. Methods for the preparation of a variety of intermediates obtained from (I) such as 3-cyclopropyl-3-hydroxypropionic acid and esters and salts thereof, 3-cyclopropylacrylic acid, and vinylcyclopropane also are disclosed.

Disclosed is a 4-step process for the preparation of alkyl esters of 1-methylcyclopropanecarboxylic acid which comprises the steps of (1) converting &ggr;-butyrolactone to &agr;-methyl-&ggr;-butyrolactone; (2) converting the &agr;-methyl-&ggr;-butyrolactone from step (1) to an alkyl 4-halo-2-methylbutyrate; (3) producing a xylene solution of the alkyl 4-halo-2-methylbutyrate; and (4) contacting the xylene solution of an alkyl 4-halo-2-methylbutyrate from step (3) with an alkali metal alkoxide under conditions of temperature and pressure which causes vaporization of (i) an alkanol as it is formed and (ii) an alkyl 1-methylcyclopropanecarboxylate as it is formed from the alkyl 4-halo-2-methylbutyrate. Also disclosed are processes whereby the alkyl 1-methylcyclopropanecarboxylate, prepared as described above, is converted to 1-methylcyclopropylamine.

Process for the preparation of alkyl 1-methylcyclopropanecarboxylate

The present invention is directed toward efficient, high-yield processes for making ascorbic acid, 2-keto-L-gulonic acid, and esters of 2-keto-L-gulonic acid. The processes comprise reacting the appropriate starting materials with a hydrolase enzyme catalyst such as a protease, an esterase, a lipase or an amidase.

Enzymatic process for the manufacture of ascorbic acid, 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid

Enzymatic process for the manufacture of ascorbic acid, 2-keto-L-gulonic

Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic

Novel poly(3-hydroxyalkanoates), such as poly(3-hydroxybutyrate), and blends of these with other polymers are disclosed. A novel process for producing these poly(3-hydroxyalkanoates) is also disclosed which entails polymerizing one or more .beta.-substituted-.beta.-propiolactone(s) under polymerization conditions in the substantial absence of water in the presence of an anionic initiator.

Biodegradable poly (3-Hydroxyalkanoate) compositions and blends

Disclosed is a novel process for the production of poly(3-hydroxyalkanoates) through the condensation polymerization of esters of 3-hydroxyalkanoic acids at a temperature of about 90.degree. to 200.degree. C. in the presence of a titanium catalyst. Also is disclosed a novel composition that is a poly(3-hydroxyalkanoate) containing predominantly carboxylic ester end groups.

Composition and process for the production of poly(3-hydroxyalkanoates)

Process for the production of poly(3-hydroxyalkanoates)

Disclosed are novel polypeptide compounds which promote the release and elevation of growth hormone levels in the blood of animals. Also disclosed are methods of promoting the release and elevation of growth hormone levels in the blood of animals using the disclosed polypeptide compounds.

Polypeptide compounds having growth hormone releasing activity

Novel compositions that are useful as nutrients are disclosed. These compounds are preferably water soluble parenteral nutrients and are glycerol esters of .beta.-acyloxybutyrates of the formula ##STR1## wherein each R is the same or different and is hydrogen, or --COCH.sub.2 CHOR'CH.sub.3), provided that at least one R is not hydrogen and wherein R' is a linear acid ester of even carbon number from 2 to 20 carbons. These compositions are useful as a substitute for glucose in feeding.

Nutritive glycerol esters of .beta.-acyloxy butyrates

Novel polypeptides which promote the release of growth hormone when administered to animals are described. These polypeptides have the formula:

Novel parenteral nutrient compositions are disclosed. These compositions are sterile aqueous solutions containing an effective amount of at least one glycerol bisacetoacetate of the formula: ##STR1## wherein one R group is hydrogen, and two R groups are --COCH.sub.2 COCH.sub.3). These compositions are useful as a substitute for glucose in intravenous feeding.

Parenteral nutrients based on watersoluble glycerol bisacetoacetates

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Kingsport, TN, United States of America

John C Hubbs