Warner-lambert Company

Other

Basf Aktiengesellschaft

Berry and Associates, Inc.

John C Hodges

Sylvester R Klutchko

Ila Sircar

Joseph Thomas Repine

Gary Louis Bolton

John S Kiely

Michael William Wilson

Clifton J Blankley

Annette M Doherty

Harriet W Hamilton

Robert V Talanian

Mark W Creswell

Bruce D Roth

Catherine R Kostlan

Walter H Moos

William Chester Patt

James S Kaltenbronn

Mel C Schroeder

Michael R Pavia

John G Topliss

Richard John Booth

Joseph Scott Warmus

Subhashis Banerjee

Sheila H DeWitt

Charles J Stankovic

David Thomas Dudley

Hamish John Allen

Michael D Taylor

Kenneth Dale Brady

Donna Reynolds Cody

Thomas A Pugsley

Richard Himmelsbach

Andres Sergio Hernandez

C John Blankley

Francis John Tinney

Terri L Boehm

James Marino Hamby

Daniele Marie Leonard

Donald John Hupe

Tariq Ghayur

Tomi Sawyer

Alfred Campbell

William H Pearson

Judith Sebolt-Leopold

Richard Gowan

Howard D H Showalter

Yam Foo Poon

A method for creating new educational, and theme party products in the form of full color 3D paper napkin entities that resemble the entity that the napkin fold or origami fold is named for. Color patterns are applied to square paper napkins or serviettes which, with the like origami fold, creates a fun challenge to the individual folder to achieve the correct folded outcome. The paper napkins are both functional for everyday use, and are folding fun for seasonal & theme parties, birthdays, and are educational as they stimulate conversation and the creative mind while folding.

Combined application of full color patterns to square paper napkins, that once folded, create napkins in 3D color images resembling the entity the napkin or origami fold is named for

The present invention provides for compounds of Formula I and II: wherein y, X, Y, Z, R, and Rhave any of the values defined there for in the specification. The compounds of formula I are useful as reagents in the isolation and the assay of PQQ dependent enzymes. Also provided are compositions comprising compounds of Formula I and II.

Methoxatin derivatives

The present invention provides for reagents for the introduction of colorimetric-oxycarbonyl protecting groups, compounds bearing colorimetric-oxycarbonyl protecting groups, and the use thereof in solid-supported organic syntheses of oligonucleotides, polypeptides, polysaccharides, and combinatorial libraries.

Colorimetric-oxycarbonyl protecting groups for use in organic syntheses

Motorcycle facial mask

Rapid purification by polymer supported quench

Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible inhibitors, selectively reversible inhibitors, chromogenic substrates, fluorogenic substrates and radiolabeled substrates/inhibitors. Pharmaceutical compositions comprising the compounds of the invention are also provided. Methods for inhibiting the proteolytic activity of Ich-1, methods for detecting the presence of Ich-1 and methods for isolating Ich-1 using the compounds of the invention are also disclosed.

Substrates and inhibitors for cysteine protease ICH-1

A process for the attachment of aromatic or heteroaromatic rings to a polymeric support via a silyl ether linkage is described. Such process involves the synthesis of a chlorodialkyl aryl or heteroarylsilane which is then coupled to a polymeric support via a hydroxyl functionality to form a polymer-bound silyl ether. Further modification provides a polymer-bound small organic molecule that is cleaved from the polymeric support under mild conditions to give an aryl or heteroaryl silanol or a compound in which the aryl or heteroaryl carbon-silicon bond is replaced with a carbon-hydrogen, carbon-halogen, carbon-hydroxyl, carbon-sulfur, or carbon&mdash;carbon bond. Such methods are useful for the preparation of a library of diverse aromatic and heteroaromatic compounds by both manual and automated synthesis.

Process for preparation of aromatic and heteroaromatic molecules

The present invention relates to N-substituted derivatives of glutamic acid of pharmaceutical interest, to pharmaceutical compositions which include compounds of the invention and pharmaceutically acceptable carriers, to methods of their preparation, and to their use in purification of interleukin-1.beta. converting enzyme (ICE).

N-substituted glutamic acid derivatives with interleukin-1.beta.

A method for the solid phase preparation of an amine by a novel synthesis is described where a diol is monoalkylated with a chloromethyl resin followed by reaction with N,N'-carbonyldimidazole to afford a resin-bound tertiary-alkoxycarbonyl-imidazole which is subsequently N-alkylated and then sequentially treated with appropriate building blocks and reagents to afford a resin-bound amine which affords the desired amine after treatment with an acid as well as other valuable intermediates used in the process.

Solid phase preparation of amines

Novel inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.

Substituted DI- and tripeptide inhibitors of protein: farnesyl

Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.

Substituted tetra- and pentapeptide inhibitors of protein: farnesyl

N-substituted glutamic acid derivatives with interleukin-1 .beta.

A method for the multiple, simultaneous synthesis of compounds comprising the steps of: 1) providing an apparatus comprising a plurality of reaction tubes having filter members on their lower ends, a reservoir member for receiving the filter member, a holder member having a plurality of apertures for supporting the reaction tubes, and a manifold member adjacent to the holder member and enclosing the upper ends of the reaction tubes; 2) charging the apparatus with reactants required for synthesis; 3) synthesizing the compounds in solution; or optionally 4) cleaving the compounds from a solid support within the apparatus.

Apparatus and method for multiple simultaneous synthesis

Growing community of inventors

Ann Arbor, MI, United States of America

John C Hodges