Senesco Technologies, Inc.

Other

Senesco, Inc.

John C Carlson

John E Thompson

Tzann-Wei Wang

Catherine Taylor

Larry Petrov

Richard Narayansingh

Dominic O Cliche

Marianne Kaup

Marianne Hopkins

Dominic 75 Old Chicopee Drive Cliche

The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Method for inducing apoptosis using apoptosis-specific EIF5-A

Expression vector encoding apoptosis-specific eIF-5A

Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis

Genes encoding an apoptosis-induced eukaryotic initiation Factor-5A (eIF-5A) and an apoptosis-induced deoxyhypusine synthase (DHS), whose expressions are induced by the onset of apoptosis, are identified. The DHS gene and the eIF-5A gene, alone or in combination, as well as inhibitors of the DHS reaction, are used to modulate apoptosis in animals and humans. For example, modulation of apoptosis in cells of animals and humans is achieved by introduction of a gene or gene fragment encoding apoptosis-induced eIF-5A, apoptosis-induced DHS, or both into the animal or human cell in antisense orientation.

DNA encoding apoptosis-induced eucaryotic initiation factor-5A and deoxyhypusine synthase and a method for controlling apoptosis in animals and humans

One pair of actuating piston and cylinder assemblies are operatively connected to the polish or sucker rod of the pump and are extended or retracted by hydraulic fluid. A further pair of piston and cylinder assemblies are operatively connected to the polish rod and are operatively connected on the underside thereof to an accumulator that includes an inert gas over oil with the gas being supplied under adjustable control conditions from a cylinder or source of high pressure gas so that these further pair of piston and cylinder assemblies counteract the weight of the pump system. On the downstroke, pressure is supplied to the upper sides of all four piston and cylinder assemblies with the two further piston and cylinder assemblies supporting the weight via the accumulator. The gas pressure is adjustable to support the desired proportion of the weight of the pump assembly and the oil being pumped thereby and other accumulators are provided in the circuits to cushion the shock load at either end of the stroke of the pump. Automatically operated switch valves and adjustable flow dividers control the oil flow to the piston and cylinder assemblies at either end of the stroke and the speed of the stroke respectively.

Pump jack assembly for wells

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Waterloo, Canada

John C Carlson