Merck + Co., Inc.

John Budavari

Edward J Grabowski

Robert F Czaja

Arthur J Zambito

William F Shukis

Crystalline salts of (R,S)-pivaloyloxyethyl esters of (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine, processes for their preparation and pharmaceutical composition are disclosed.

Crystalline salts of L or (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine

Crystalline salts of (R,S)-pivaloyloxyethyl esters of (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine and processes for their preparation are disclosed.

Process for crystalline salts of L or

Disclosed is a crystalline form of diastereomeric L-.alpha.-methyldopa POE ester, also referred to as (R),(S)-.alpha.-pivaloyloxyethyl-(S)-3-(3,4-dihydroxyphenyl)-2-methylalani nate and a process for its isolation. Also disclosed is an improved process for the formation of diastereomeric L-.alpha.-methyldopa POE ester.

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Watchung, NJ, United States of America

John Budavari