Health Protection Agency

Dynport Vaccine Company LLC

The Secretary of State for Health

John Brehm

Ian McEntee

Philip Vincent

Randall K Lapcevich

George Jack

Juan Arroyo

Rossalyn Brehm

Michael Herbert

Nigel Allison

Barbara T Solow

Ian Mcentee

Barbara T Dynport Vaccine Company Llc Solow

Juan Dynport Vaccine Company Llc Arroyo

Randall K Dynport Vaccine Company Llc Lapcevich

A polynucleotide sequence is provided comprising a nucleic acid sequence encoding recombinant Protective Antigen (rPA). Also provided are expression vectors and host cells comprising the polynucleotide sequence of the invention, and methods for producing rPA.

Preparation of protective antigen

A polynucleotide sequence is provided, comprising: a nucleic acid sequence having at least 75% identity to SEQ ID NO: 1, wherein said nucleic acid sequence encodes recombinantProtective Antigen (rPA); or a fragment of said nucleic acid sequence wherein said fragment encodes a fragment of recombinantProtective Antigen (rPA). Also provided are expression vectors and host cells comprising the polynucleotide sequence of the invention, and methods for producing rPA or a fragment thereof. The invention further provides antigenic compositions and corresponding methods and uses for inducing an immune response.

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Growing community of inventors

Salisbury, United Kingdom

John Brehm