Abbott Diabetes Care Inc.

Therasense, Inc.

Nippon Kayaku Kabushiki Kaisha

Toyota Tsusho America, Inc.

Eric A. Button

John B. Buse

Steven D. Wittlin

Kathleen Dungan

Shuhei Kato

Toshio Tanabe

John Bernard Buse

Alan Charles Moses

Steven D Wittlin

Eric A Button

A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.

Integrated sample acquisition and analyte measurement method

Method for integrated sample acquisition and analyte measurement device

Integrated sample acquisition and analyte measurement device

Methods of determining analyte concentration

The invention is a method of measuring blood glucose excursions in general, and postprandial hyperglycemia in diabetic patients in particular, by the 1,5-anhydroglucitol assay (1,5-AG) or A1C/1,5-AG assay combination. 1,5-AG levels and percent changes of 1,5-AG levels in short period are indicative of differing postmeal glucose levels in moderately-controlled diabetic patients with similar A1C levels. Thereby 1,5-AG assay is useful to identify diabetic patients who may be at risk for cardiovascular complications which would not be identifiable by A1C levels alone. Furthermore, ratios of A1C divided by 1,5-AG in each patient are superior indicators to 1,5-AG levels.

Method of estimation of blood glucose excursions in diabetic patients using 1,5-anhydroglucitol (1,5-AG) assay

Methods of determining concentration of glucose

Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator

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Chapel Hill, NC, United States of America

John Bernard Buse