Intermune, Inc.

Blade Therapeutics, Inc.

John Beamond Nicholas

Brad Owen Buckman

Kumaraswamy Emayan

Scott D Seiwert

Johnnie Y Ramphal

Shendong Yuan

Marc Adler

Jingyuan Ma

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Calpain modulators and therapeutic uses thereof

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to macrocyclic &#x3b1;-keto amide derivatives and their use as therapeutic agents.

Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

Anti-fibrotic pyridinones

The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.

Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.

Growing community of inventors

Redwood City, CA, United States of America

John Beamond Nicholas