Other

Robarts Research Institute

The University of Western Ontario

John Barrett

Grant McFadden

Olaf Nigol

Marianne Stanford

Martin A Green

Grant Mcfadden

The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.

Use of a combination of Myxoma virus and rapamycin for therapeutic treatment

Myxoma viruses that are deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M 136, M-T4 and M-T7 are useful for treating cancer.

Myxoma virus mutants for cancer treatment

The invention relates to ACSR conductors having two or more layers of conductor strands wound helically around a steel core, the layers being wound alternately in right-handed and left-handed helices. The AC/DC resistance ratio of such a conductor can be greatly reduced by appropriate selection of the lay factors of the strand layers in relation to the cross sectional areas of the respective layers. The unbalanced mechanical torque can also be greatly reduced by appropriate selection of the lay factors of the strand layers in relation to the means diameters of the layers and the outside diameter of the conductor.

Low-loss and low-torque ACSR conductors

Cold drawn carbon steel wire, more particularly stranded galvanized wire for use in overhead power transmission lines, is heat treated in the untensioned state for a period of at least one hour at a temperature in the range 150.degree. C.-200.degree. C. The preferred temperature is about 175.degree. C. The treated wire has a reduced susceptibility to permanent elongation under tensile stress. ACSR conductors incorporating such wire as the steel reinforcement have a greatly reduced sag under heavy ice loading.

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London, Canada

John Barrett