The Rockefeller University

Baxter International Inc.

The United States of America as Represented by the Department of Health

North American Vaccine, Inc.

John B Zabriskie

Francis Michon

Milan S Blake

Joseph Y Tai

Jason D Bannan

Shridhar P Damle

Howard Fillit

John D Gregory

Susan E Swedo

Henrietta L Leonard

William W Hall

Kumar Visvanathan

Stanley E Read

Michael Lyons

Daniel R Buskirk

This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A polysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, the group A polysaccharides may be associated with an adjuvant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at risk of contracting group A Streptococcal infections and disease namely adults, pregnant women and in particular infants and children.

Group A streptococcal polysaccharide immunogenic compositions and methods

This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof. The invention also relates to serum antibodies induced by the peptides and carrier-conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins. The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates isolated and purified to nucleic acids encoding the peptides of the invention and transformed host cells containing those nucleic acids.

Peptides useful for reducing symptoms of toxic shock syndrome and septic shock

This invention relates to compositions and methods for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity, of toxic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof, and their use to induce serum antibodies. The invention also relates to serum antibodies induced by the peptides and carrier-conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins. The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates isolated and purified to nucleic acids encoding the peptides of the invention and transformed host cells containing those nucleic acids.

Peptides useful for reducing symptoms of toxic shock syndrome

A method of identifying individuals who have, or who are at risk of developing, autoimmune neuropsychiatric disorders is disclosed. The invented method relies on detection of the B lymphocyte antigen, D8/17. The invented method can conveniently be carried out as a simple blood test.

Method of identifying persons susceptible to autoimmune neuropsychiatric

This invention relates to treating vetrovirus of the leutivirous group with colchicine.

Use of colchicine for the control of retroviruses

Purified glomerular proteoglycans are used as a basis for a diagnostic test for glomerulonephritis in humans involving an immunological reaction between the purified proteoglycans and patient area. A new method for purification of glomeruli proteoglycan antigens is described using guanidine extraction.

Kit for the determination and diagnosis of non-goodpasture

Purified glomerular proteoglycans are used as a basis for a diagnostic test for glomerulonephritis in humans involving an immunological reaction between the purified proteoglycans and patient sera. A new method for purification of glomeruli proteoglycan antigens is described using guanidine extraction.

Method for determination and diagnosis of non-goodposture

Monoclonal antibodies which react specifically with a complementary rheumatic fever associated antigen on human B-lymphocytes derived from hybridoma cell line HB8783, process for preparing such antibodies, the use of antibodies for detecting rheumatic fever in mammals and test kit containing the antibodies.

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New York, NY, United States of America

John B Zabriskie