Abbott Cardiovascular Systems, Inc.

Cardiac Pacemakers, Inc.

Advanced Cardiovascular Systems, Inc.

Abbott Laboratories Corporation

Heart Rhythm Technologies, Inc.

Poway Retinal Technologies, LLC

John Arthur Simpson

Bruce M Wilson

Wade A Bowe

Jonathan P Durcan

Matthew J Gillick

John Francis Boylan

Robert C Hayzelden

Puneet Kamal Singh Gill

Jessie Delgado

Wayne E Cornish

Pamela A Kramer-Brown

Michael R Bialas

Robert P Barbier

Thomas Haslinger

Marshall L Sherman

Justin K Mann

Daniel G Brown

Leonard Darius Barbod

Wouter Erik Roorda

Jeong Soo Lee

John E Papp

Michael L Green

Marc Gianotti

Peter J D'Aquanni

Frank E Manning

Thomas M Castellano

Ryan Grandfield

Stephen D Pacetti

Jeffrey A Hall

Jesse Flores

David S Wood

Weimin Sun

David H Burkett

William Earl Webler, Jr

Lili Liu

August R Yambao

Travis Richard Yribarren

Veerichetty A Kadhiresan

Eugene J Jung

Mina W Chow

Jasper Benke

Charles R Peterson

Jessica G Chiu

Emmanuel C Biagtan

Dagmar Beyerlein

William E Webler, Jr

Jeffrey F Dooley

Curt A Novak

Ramon Arana

Jason Phillips

David P Strauss

Vincent Bavaro

Neftali Fernandez

Aaron Baldwin

Duane M DeMore

Matthew James Chludzinski

William S Chin

Robert Alcantara

Sarah A Nelson

Lenny Barbod

Ramon Torres

Devon Brown

Quan Ritchie

Michael Plattner

Austin M Leach

Andrea M Moore

Jakub Truty

Kayla L Calvert

Matt Gillick

Patrick J Fitzgerald

Gabriel Asongwe

Chris Davis

Pablito Buan

Raleigh A Purtzer

Kathryn E Lockwood

Paul E Tornambe

Carl P Frick

R Todd McKinney

John J Nelson, Iii

Barbara Stramberg

Jeffrey A Calhoun

Russ E Anderson

Vincent P Bavaro

Scott J Rusk

Jessica M Saenz

Robert J Peralta

Michelle E Alexander

Arthur R Tyre

Vincent Peter Bavaro

Peter D'aquanni

R Todd Mckinney

Bruce A Wilson

Barbara Stamberg

Wouter Eric Roorda

Gabriel F Asongwe

The present disclosure is directed to a multi-segment device comprising an elongate first portion comprising a first metallic material, an elongate second portion comprising a different metallic material, the first and second elongate portions being directly joined together end to end, a heat affected zone surrounding an interface of the elongate first portion and the elongate second portion, a shapeable distal end formed from at least a portion of the elongate second portion, a coil disposed about a portion of the elongate second portion.

Methods for counteracting rebounding effects during solid state resistance welding of dissimilar materials

Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium, tungsten, and nickel, and methods for their manufacture. Tungsten is present above its solubility limit (about 15%) at ambient temperature, but is still only present as a super-saturated, primarily single-phase material exhibiting an FCC microcrystalline structure.

Methods for manufacturing radiopaque intraluminal stents comprising cobalt-based alloys with supersaturated tungsten content

A stent comprising a cobalt-based alloy comprising 18-50 weight % cobalt (Co), 10-25 weight % chromium (Cr), 10-15 weight % tungsten (W), 0-2 weight % of manganese (Mn), 0-3 weight % iron (Fe), and 10-65 weight % metal member selected from a platinum group metal.

Radiopaque intraluminal stents

A guidewire for use in penetrating through complex and stenosed lesions. The distal tip of the guidewire has a roughened surface to increase frictional engagement with calcified and fibrous tissue to increase the penetration of the distal tip and the guidewire into and through the lesion and reduce the likelihood of deflection of the guidewire tip. The average surface roughness of the distal tip is in the range from 1 micron to 200 microns.

Guide wire tip having roughened surface

The present disclosure is directed to a multi-segment device, such as an intravascular guide wire. The multi-segment device includes an elongate first portion comprising a first metallic material, an elongate second portion comprising a different metallic material, the first and second elongate portions being directly joined together end to end by a solid-state weld, and a heat affected zone surrounding an interface of the weld where the first and second portions are joined together, wherein the heat affected zone has an average thickness of less than about 0.20 mm.

A stent having a cobalt-based alloy, wherein the cobalt-based alloy is free of nickel (Ni), the cobalt-based alloy including 10-65 weight % metal member selected from a platinum group metal, a refractory metal, or combinations thereof, 15-25 weight % chromium (Cr), 4-7 weight % molybdenum (Mo), 0-18 weight % iron (Fe), and 22-40 weight % cobalt (Co).

A method of pretinning a guidewire core made of shape memory alloy and having an elongate axis, comprising: placing a ball of solder in a pocket in a soldering block; melting the ball of solder; holding a guidewire core over the ball of solder; lowering the guidewire core into the ball of solder; removing the guidewire from the ball of solder.

Method for selectively pretinning a guidewire core

Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium, tungsten, and nickel. Tungsten is present above its solubility limit (about 15%), but is still only present as a super-saturated, primarily single-phase material exhibiting an FCC microcrystalline structure.

Radiopaque intraluminal stents comprising cobalt-based alloys with primarily single-phase supersaturated tungsten content

The present disclosure is directed to multi-segment intraluminal guide wires including an elongate distal portion comprising a first metallic material (e.g., nitinol), an elongate proximal portion comprising a second metallic material (e.g., stainless steel). The distal and proximal portions may be directly joined together end to end by a solid-state weld joint. A diameter of the weld region surrounding the weld joint on either side of the weld joint may be reduced (e.g., ground down) relative to the diameter of the distal and proximal portions of the guide wire on either side of the weld region. A stiffness adjusting sleeve may be disposed over the weld joint so that a transition profile of bending stiffness across the weld region is gradual, rather than abrupt across the distal portion of the guide wire to the proximal portion of the guide wire. A polymer jacket may cover the sleeve and distal portion.

Mechanisms for improving the stiffness transition across a dissimilar metal weld joint

Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, precious metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Refractory metals include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, and precious metals include silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute at least partially for nickel, such that the alloy exhibits reduced nickel content, or is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel.

Radiopaque intraluminal stents comprising cobalt-based alloys containing one or more platinum group metals, refractory metals, or combinations thereof

A method of making a core metal element for a medical guidewire including providing a wire of nickel titanium alloy having a length that includes a proximal portion having a first diameter and a distal portion having a second diameter. The method further includes applying cold work to the distal portion and not applying cold work to the proximal portion, thereby imparting to the distal portion a third diameter that is smaller than the second diameter; and then applying a reducing process to the wire whereby the proximal portion is reduced to have a fourth diameter that is less than the first diameter.

Guidewire with varying properties

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Carlsbad, CA, United States of America

John Arthur Simpson