University of Durham

The Secretary of State for Environment, Food and Rural Affairs

Department for Environment, Food and Rural Affairs

John Arthur Gatehouse

Elaine Charlotte Fitches

Prashant Shivasharan Pyati

Sheng Yang

John Patrick Edwards

Methods of increasing the biological activity of toxins. Methods of increasing the biological activity of pesticide toxins through the incorporation of pro-regions into nucleic acid constructs for the production of said toxins.

Pesticidal fusion protein improvements

The present invention relates to the development of fusion proteins based on peptide toxins as pesticides. The invention also relates to transgenic plants encoding said peptides and their utility in pest management.

Pesticides

A fusion protein comprising a translocating moiety and a toxic moiety wherein the translocating moiety comprises a plant protein that is capable of acting as a carrier to translocate the toxic moiety across the gut wall of at least one plant pathogen, wherein the toxic moiety is adapted to be effective as a toxic agent following translocation; composition comprising the protein, methods for preparation thereof; polynucleotide encoding the fusion protein, vector comprising the polynucleotide, host cell and transgenic plant cell or plant that is resistant to pathogen, expressing the fusion protein, and uses thereof in combatting plant pathogens and in insect control.

Growing community of inventors

Durham, United Kingdom

John Arthur Gatehouse