University of South Florida

H. Lee Moffitt Cancer Center and Research Institute, Inc.

John Arrington

Robert J Gillies

Dmitry B Goldgof

Lawrence O Hall

Robert A Gatenby

Olya Stringfield

Yoganand Balagurunathan

Natarajan Raghunand

Virtually every cancer patient is imaged with CT, PET or MRI. Importantly, such imaging reveals that tumors are complex and heterogeneous, often containing multiple habitats within them. Disclosed herein are methods for analyzing these images to infer cellular and molecular structure in each of these habitats. The methods can involve spatially superimposing two or more radiological images of the tumor sufficient to define regional habitat variations in two or more ecological dynamics in the tumor, and comparing the habitat variations to one or more controls to predict the severity of the tumor.

Radiologically identified tumor habitats

Growing community of inventors

Tampa, FL, United States of America

John Arrington