The United States of America, as Represented by the Secretary, Department of Health and Human Services

General Electric Company

Koninklijke Philips Corporation N.v.

Leland Stanford Junior University

Johns Hopkins University

The United States of America as Represented by the Secretary of the Office of Technology Transfer, National Institute of Health

John Andrew Derbyshire

Daniel Alfredo Herzka

Elliot R McVeigh

John Mark Pauly

Graham Arnold Wright

Charles H Cunningham

Pelin Aksit

Jeffrey Alan Stainsby

Juan Manuel Santos

A magnetic resonance imaging (MRI) system, comprising a magnetic resonance imaging scanner. The MR scanner comprises a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation, the subject represented by a spatial distribution of magnetizations; a radio frequency (RF) coil system configured to irradiate a plurality of radio frequency (RF) pulses into a region of interest of the subject and to detect a plurality of RF response signals emitted from the region of interest; a gradient coil system configured to provide a perturbation of the main magnetic field B0 using a gradient pulse sequence that causes the RF response signals to encode the spatial distribution of magnetizations in a Fourier domain on a plurality of read-out paths; and a controller in communication with the RF coil system and the gradient coil system to synchronously provide the RF coil system with the plurality of RF pulses and the gradient coil system with the gradient pulse sequence. The gradient pulse sequence comprises a navigator pulse that causes one of the plurality of RF response signals to encode the spatial distribution of magnetizations in the Fourier domain on a pre-determined navigator path that represents a fixed projection of the region of interest of the subject, the pre-determined navigator path is suitable to be in a direction different from directions of the read-out paths, and the fixed projection of the subject is capable of tracking a motion of the subject.

Apparatus and method for magnetic resonance imaging with high spatial temporal resolutions

A system and method for MR magnetic field mapping includes a computer programmed to acquire a first data point at a first location in a first phase image data set, a second data point at the first location in a second phase image data set, a third data point at the first location in a third phase image data set. The first, second, and third phase images are acquired using a first, second, and third TE, respectively. Phase wrapping does not occur among the first and second phase image data sets; however, phase wrapping does occur among the second and third phase image data sets. The computer is also programmed to determine a magnetic field inhomogeneity, wherein the determination of the magnetic field inhomogeneity is based on the first, second, and third data points.

Three-point method and system for fast and robust field mapping for EPI geometric distortion correction

In an imaging method, periodic maintenance radio frequency pulses (&#x3b1;, &#x2212;&#x3b1;) are applied to maintain a steady state magnetic resonance excitation in an imaging region. Readout () of imaging data from the imaging region is performed during selected intervals between maintenance radio frequency pulses. A spatially selective blood signal suppression sequence (') is performed during selected other intervals between maintenance radio frequency pulses. The blood signal suppression sequence suppresses a blood signal in a suppression region different from the imaging region. The blood signal suppression sequence has substantially no zero the moment applied magnetic field gradient.

Black-blood steady-state free precession magnetic resonance imaging

A method for fat-suppressed imaging is disclosed. Such a method may include storing a first spectral component of an echo signal formed at TR/2 from a sample, suppressing a second spectral component of the echo signal at TR/2, re-exciting the stored spectral component after suppressing the second spectral component, and producing an image of the sample based on the re-excited stored spectral component.

Spectrally selective suppression with steady-state free precession

A method that exploits the intrinsic selectivity of steady-state free precession (SSFP) to perform spectral suppression is disclosed. Such a method avoids the need to incorporate additional spectrally selective pulse sequence elements. The scheme is based on breaking the FISP imaging sequence into short trains having, for example, 8&#x2013;64 RF pulses. At the moment of echo formation (i.e., TE=TR/2) after the last full RF pulse of the train, water signal is z-stored. Residual transverse magnetization, which include isochromats phase-opposed to the on-resonance water, is gradient crushed and RF spoiled. The stored magnetization is subsequently re-excited with little disturbance to the on-resonance steady-state water signal. The additional time required to perform the steady-state interruption is typically as little as a single TR, minimally affecting the efficiency of the imaging process. The sequence can be employed repetitively, greatly reducing the amplitude of fat signals throughout a real-time or cine imaging process.

A RF Excitation pulse for MRI applications has built-in saturation sidebands, thereby reducing the time for an excitation sequence. The pulse is created using the Shinnar-Le Roux (SLR) transform and designing beta-polynomials for a desired image slice excitation and for saturation of RF excitation such as by de-phasing in regions adjacent to the desired image slice. The beta-polynomials are combined and an inverse SLR transform creates the RF pulse from the combined beta-polynomial.

Growing community of inventors

Silver Spring, MD, United States of America

John Andrew Derbyshire