Smithkline Beecham Corporation

Glaxosmithkline LLC

John Albert Ray

Amarjit Sab Randhawa

Rodolfo Cadilla

Philip Stewart Turnbull

Andrew Lamont Larkin

Eugene Lee Stewart

Darryl Lynn McDougald

Huiquiang Zhou

Katherine Stetson

Vicente Samano

Michael Tolar Martin

David Norman Deaton

Aaron Bayne Miller

Dennis Heyer

Subba Reddy Katamreddy

John George Catalano

David Gene Barrett

Michael Scott McClure

Thomas N Wheeler

John Fred Eaddy, Iii

Huiqiang Zhou

Darryl Lynn Mcdougald

This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Chemical compounds

Compounds of formula (I): with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation.

Triphenylethylene compounds as selective estrogen receptor modulators

Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.

Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss

Anilide herbicide derivatives

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Durham, NC, United States of America

John Albert Ray