Elan Pharmaceuticals, Inc.

Pharmacia & Upjohn Company

Other

Incuron, LLC

Pfizer Corporation

Pharmacia Corporation

John Alan Tucker

Valerie Ann Vaillancourt

Varghese John

Andrei V Gudkov

Louis Brogley

Katerina Gurova

Sergey Sviridov

Catherine Burkhart

Leonid Brodsky

Andrei Purmal

Michael A Pleiss

Steven Paul Tanis

Joseph Walter Strohbach

Roy K Hom

Suvit Thaisrivongs

Heinrich Josef Schostarez

Paul D May

Scott D Larsen

Martin Durham Meglasson

Shon R Pulley

Karen Rene Romines

Eugene D Thorsett

Jay S Tung

Francine S Grant

Arthur Glenn Romero

Darren B Dressen

Mark E Schnute

Michael S Dappen

Steven Ronald Turner

Michel Maillard

Martin Neitzel

Jon Eric Hawkinson

Michael Ye

Ramesh Kasar

Jose Aquino

Sarah Bartulis

Mohammed A Khan

Neerav Shah

Lee H Latimer

Jing Wu

Ruth Elizabeth TenBrink

John W Mickelson

Simeon Bowers

Steven J Brickner

Robert William Scott

Albert W Garofalo

James Beck

Barbara Jagodzinska

Andrea Gailunas

Gary D Probst

Jennifer Sealy

Ashley C Guinn

Brian Alan Sherer

David W G Wone

Jon S Jacobs

Scott A Jenkins

Michele M Cudahy

Christopher Frederick Matthews

Olivier Bezencon

Ruth Tenbrink

Ying Zi Xu

Debra A Ulanowicz

Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. (I), (II).

Carbazole compounds and therapeutic uses of the compounds

Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. 

A loader for inserting an ammunition cartridge into a gun's magazine includes a body operable to hold two or more ammunition cartridges, a retainer to prevent a cartridge held by the body from leaving the body and operable to release a held cartridge from the body to position the cartridge for insertion into a gun's magazine, and an insertion component to exert pressure on a positioned cartridge to insert the cartridge into the gun's magazine. When the loader is used to insert a cartridge into a gun's magazine, the insertion component extends into the gun's carrier opening, a cartridge from the body is positioned on the insertion component, and the body is then moved relative to the gun's magazine. By holding the cartridges with the body and forcing a positioned cartridge into the gun's magazine with the insertion component, one can quickly and efficiently load a gun's magazine.

Speed loader for a gun, and related systems and methods

The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

Substituted hydroxyethylamine aspartyl protease inhibitors

The present invention relates to methods and compounds useful in the preparation of compounds of the formula (I). 

Methods for the preparation of HCV polymerase inhibitors

This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting &#x3b2;-amyloid peptide release and/or synthesis, a method for inhibiting &#x3b3;-secretase activity, and a method for treating neurological disorders associated with &#x3b2;-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.

Acylated amino acid amidyl pyrazoles and related compounds

Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.

Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists

Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

N- (3-amino-2-hydroxy-propyl) substituted alkylamide compounds

Disclosed are compounds of the formula: where variables Q, Z, X, R, R, R, and Rare defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.

2-amino- and 2-thio- substituted 1,3-diaminopropanes

The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation 

Substituted aminoalcohols useful in treatment of Alzheimer's disease

The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Substituted ureas and carbamates

The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Hydroxypropyl amides for the treatment of Alzheimer's disease

The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Benzamide 2-hydroxy-3-diaminoalkanes

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South San Francisco, CA, United States of America

John Alan Tucker