University of Florida Research Foundation, Incorporated

John A Zoltewicz

William Reade Kem

Edwin M Meyer

Michael P Cruskie

Roger Lee Papke

Arthur Day

Katalin Prokai-Tatrai

Christopher M De Fiebre

Franz Van Haaren

Method of using anabaseine, DMAB-anabaseine, and anabaseine for stimulating brain cholinergic transmission and a method of making anabaseine.

Use of nicotinic analogs for treatment of degenerative diseases of the nervous system

This invention relates to compositions for benzylidene- and cinnamylidene-anabaseines and methods for using these compositions for treating conditions associated with defects or malfunctioning of nicotinic subtypes brain receptors. These compositions target the alpha7 receptor subtype with little or no activation of the alpha4beta2 or other receptor subtypes.

Methods of use and compositions for benzylidene- and

A process for synthesis of anabaseine using nicotinoyl piperidone salt having the formula ##STR1## wherein R.sub.1 and R.sub.2 are lower alkyl and M is a group I alkaline metal.

Synthesis of nicotinic analogs

Anabaseine derivatives useful in the treatment of degenerative diseases

A novel synthesis of anabaseine using an animal nicotinoyl piperidone salt having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are lower alkyl, or R.sub.1 and R.sub.2 forms a morpholine or piperidine ring and the metal is a group I alkaline metal.

Growing community of inventors

Gainesville, FL, United States of America

John A Zoltewicz