The Wellcome Foundation Limited

John A Wyatt

John P Larkin

Ian H Smith

David A Pulman

Malcolm H Black

John B Weston

Deborah J Hawkes

Pesticidal bicyclo-octanes are of the formula ##STR1## where R is a substituted or unsubstituted aliphatic or aromatic group, R' and R.sup.3 are H or a substituted or unsubstituted aliphatic or aromatic group, R.sup.2 is a substituted or unsubstituted heterocyclic group containing at least one ring nitrogen and is preferably a 3- or 4- pyridyl group, Z is CH.sub.2 CH.sub.2, CH.sub.2 O--CH.sub.2 S or COCH.sub.2 or CH(OR.sup.5)CH.sub.2 where R.sup.5 is H, alkyl, acyl or carbamoyl at Y and Y' are O or S(O).sub.m where m is 0, 1 or 2. Various methods for their preparation are described.

1-heterocyclic bicyclo-octanes

The present invention provides compounds of the formula (I): ##STR1## wherein R is a C.sub.2-10 non-aromatic hydrocarbyl group, a C.sub.2-10 non-aromatic hydrocarbyl group substituted by, or methyl substituted by cyano, halo, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy substituted by halo, or a group S(O).sub.m R.sup.4 where R.sup.4 is C.sub.1-4 alkyl optionally substituted by halo and m is 0, 1 or 2, or R is phenyl or phenyl substituted by C.sub.1-4 alkoxy, C.sub.1-3 alkyl, C.sub.2-4 alkynyl, halo, C.sub.1-4 haloalkyl, cyano or a group S(O).sub.m R.sup.4 as defined hereinbefore; R.sup.1 and R.sup.2 may be the same or different, and each is hydrogen, or a C.sub.1-3 aliphatic group, or a C.sub.1-3 aliphatic group substituted by halo; R.sup.3 contains between 3 and 18 carbon atoms and is a group R.sup.5 wherein R.sup.5 is a C.sub.1-13 non-aromatic hydrocarbyl group, a C.sub.1-3 non-aromatic hydrocarbyl group substituted by a C.sub.2-4 carbalkoxy or cyano group and/or by one or two hydroxy groups and/or by one to five halo atoms which are the same or different and/or by one to three groups R.sup.6 which are the same or different and each contains one to four hetero atoms, which are the same or different and are chosen from oxygen, sulphur, nitrogen and silicon, 1 to 10 carbon atoms and 0 to 6 fluoro or chloro atoms or R.sup.3 is a 6-membered aromatic ring substituted by cyano and/or by one to three groups R.sup.6 and/or by a group --C.tbd.CH, --C.tbd.C--R.sup.5 or C.tbd.C-halo and/or by one to five halo atoms and/or by one to three C.sub.1-4 haloalkyl groups wherein R.sup.5 and R.sup.6 are as hereinbefore defined; and Y is selected from methylene, oxygen and S(O).sub.t', Y' is selected from oxygen and S(O).sub.t' where t' and t' are each selected from 0, 1 or 2; and t is 1 or 2, processes for their preparation, formulations containing them and their use in the control of pest infestation.

Pesticidal compounds

Growing community of inventors

Berkhamsted, United Kingdom

John A Wyatt