Abbott Molecular Inc.

Abbott Laboratories Corporation

John A Salituro

Shihai X Huang

John J Carrino

Klara Abravaya

Brian J Erickson

Ronald L Marshall

Ning Tang

Edward K Pabich

Wai-Bing X Mak

Matthew T Manlove

John D Burczak

Paul A Klonowski

Larry E Morrison

John R Hackett

Ka-Cheung X Luk

Jeffrey D Wuitschick

Tomasz Krupinski

Chad Dunn

John R Ertl

Paul M Jung

Anna Sobol

John Karavitis

Ka-Cheung Luk

The disclosure is directed to methods, kits, and compositions for amplifying and detecting a human immunodeficiency virus-1 (HIV-1) in a sample, which comprises a variety of combinations of forward oligonucleotide primers, reverse oligonucleotide primers, and oligonucleotide probes.

Assay for detecting human immunodeficiency virus (HIV)

The present invention relates to primers, probes, primer sets, primer and probe sets, methods and kits for detecting human papillomaviruses, human beta globin sequences and human papillomaviruses and human beta globin sequences in a test sample.

Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples

A double-stranded nucleic acid hybridization probe and methods of using the same are described. The probe described is particularly suited for real-time RT-PCR reactions and has high tolerance to mismatches.

Double stranded linear nucleic acid probe

The present invention provides novel and non-obvious improvements to dried blood spot testing for HIV-1 viral load useful for diagnosis and monitoring treatment progression.

Automated HIV-1 viral load testing procedure for dried spots

The method provided herein is a method for detecting a target sequence in a test sample. Generally, the method comprises forming a reaction mixture comprising a test sample, amplification reagents, a first primer, and a second primer wherein the concentration of the first primer in the reaction mixture is 15% to 250% percent greater than the concentration of the second primer. The target sequence is amplified according to any amplification protocol that employs the primer sequences to generate copies of the target sequence that include a product from the first and second primers. A probe is hybridized to the amplification product from the first primer to form a hybrid complex; and the hybrid complex is detected as an indication of the presence of the target sequence in the test sample.

Method for using unequal primer concentrations for generating nucleic acid amplification products

Provided herein is a method for detecting the presence of a target nucleic acid sequence in a sample. The present method uses a combination of dual labeled probes and heterogeneous detection methods.

Analyte detection process using dual labeled probes

The present invention relates to oligonucleotide probes useful in detecting, e.g. by hybridization or the ligase chain reaction, Chlamydia trachomatis DNA in the presence of other related DNA. The present invention is also directed to methods of detecting Chlamydia trachomatis organisms in a sample using the ligase chain reaction.

Oligonucleotides specific for the MOMP gene sequence and methods for the

Oligonucleotides and methods for the detection of Chlamydia trachomatis

Oligonucleotides and methods for the detection of chlamydia trachomatis

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Union Grove, WI, United States of America

John A Salituro