University of Illinois

Northwestern University

Other

University of Pennsylvania

Washington University

Lucent Technologies Inc.

United States of America As Represented by the Secretary of the Air Force

Harvard College

Dow Corning Corporation

Purdue Research Foundation

University of Minnesota

Sandia Corporation

University of Colorado

Vanderbilt University

University of Arizona

John A Rogers

Etienne Menard

Ralph G Nuzzo

Matthew Alexander Meitl

Dahl-Young Khang

Yugang Sun

Heung Cho Ko

Zhengtao Zhu

Yonggang Huang

Mark Stoykovich

Keon Jae Lee

Jongseung Yoon

Alfred Baca

Dae-Hyeong Kim

Won Mook Choi

Jong-Hyun Ahn

Michael Motala

Chang-Jae Yu

Andrew Evert Carlson

Sang-Il Park

Jungil Choi

Fiorenzo G Omenetto

Placid M Ferreira

Sungbong Kim

Dae Hyeong Kim

Jizhou Song

Brian Litt

Jonathan Viventi

Jong Hyun Ahn

Shuai Xu

Johnathan T Reeder

Hoon-sik Kim

Tyler R Ray

David L Kaplan

Hanqing Jiang

Andrew Bonifas

Jang-Ung Park

Jonathan A Fan

Yihui Zhang

Anthony R Banks

Jeonghyun Kim

Xian Huang

Roozbeh Ghaffari

Seok Kim

Sang Il Park

Philipp Gutruf

Kun Hyuck Lee

YuHao Liu

Yurina Sekine

Shawn Mack

Amay J Bandodkar

Rak Hwan Kim

Michael Raymond Bruchas

Ming Ying

Sheng Xu

Marvin J Slepian

Igor R Efimov

Jianjun Cheng

Hao F Zhang

Anne K Shim

Anthony Stewart Campbell

Reza Saeidpourazar

Yu Yang

Hu Tao

Jason Amsden

Deepkishore Mukhopadhyay

Canan Dagdeviren

Angus A Rockett

Woon-Hong Yeo

Andrew Alleyne

Hanze Ying

Yi Zhang

Ahmad Ehteshamul Islam

Siddharth Krishnan

Sandipan Mishra

Yanfeng Zhang

George M Whitesides

Qing Cao

David C Duffy

Matthew MacEwan

Christi Kay Madsen

Douglas Ray Adkins

John Arthur Carlisle

Robert K Grubbs

Todd Richard Salamon

Muhammad Ashraful Alam

Patrick Lewis

Chi Hwan Lee

Gregory Robert Bogart

Moonsub Shim

William B McBride

Michael Charles Brothers

Bharat Raj Acharya

Tae-il Kim

Wilson Ray

Mitchell H Rubenstein

Olivier J A Schueller

Mark Does

Scott T Brittain

Systems and methods are disclosed for an electrical sensing, pacing, and ablation device comprising a bendable and stretchable balloon catheter and a bendable and stretchable first layer connected to or embedded in said balloon catheter, where the first layer has an electrode array with a plurality of electrodes. The is also a bendable and stretchable second layer connected to or embedded in the balloon catheter, and the second layer has a pressure sensor array with a plurality of pressure sensors.

Systems and methods for selective his bundle mapping and pacing

An implantable bioresorbable radio frequency (RF) coil for high-resolution and high-specificity post-surgical evaluating or monitoring with magnetic resonance imaging (MRI) is disclosed. The coil includes a bioresorbable conductor configured to be resorbed within a patient while the coil is implanted in the patient. In one embodiment, the target application of this coil is the evaluation or monitoring (via MRI) of peripheral nerve regeneration following surgical repair.

Bioresorbable RF coils for post-surgical monitoring by MRI

The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.

Methods and devices for fabricating and assembling printable semiconductor elements

This invention discloses a sensor for measuring parameters of sweat from a skin, comprising a flexible structure comprising a fluid passage having inlet and outlet, the flexible structure being detachably attached to the skin and configured such that sweat enters the inlet as the sweat releases from the skin and flows through the fluid passage into the outlet; a thermal actuator disposed on the flexible structure over the fluid passage and configured to operably provide heat to flow of the sweat through the fluid passage; a first thermistor disposed on the flexible structure over the fluid passage between the inlet and the thermal actuator and configured to operably measure a first temperature of the sweat thereon; and a second thermistor disposed on the flexible structure over the fluid passage between the thermal actuator and the outlet and configured to operably measure a second temperature of the sweat thereon.

Systems and methods for wireless, real-time monitoring parameters of sweat and applications of same

Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.

Epidermal microfluidic sensor for sweat collection and analysis from aquatic athletes

Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device comprises a tissue penetrating member having a distal end and a proximal end, the tissue penetrating member configured to penetrate the tissue of the patient to be inserted into the tissue, wherein the tissue penetrating member is at least partially optically transparent along a surface of the tissue penetrating member positioned between the distal end of the tissue penetrating member and the proximal end of the tissue penetrating member to provide optical transmission of at least a portion of the light through the surface of the tissue penetrating member, thereby allowing at least the portion of the light to be delivered into the tissue of the patient when the tissue penetrating member is inserted into the tissue; and a substrate that supports the tissue penetrating member.

Devices and methods for light delivery

A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

Microfluidic systems for epidermal sampling and sensing

Provided are actuation devices, virtual reality devices formed from the actuation devices, and related virtual reality methods. The devices may comprise a plurality of spatially distributed actuators, each actuator configured for interacting with a biological skin surface; a wireless controller configured to receive operative command signals to control each of the actuators; and a wireless power system to power the actuators. Also provided are unique layouts of multiple interconnected devices to achieve large area coverage.

Epidermal virtual reality devices

A system for measuring a radiant exposure of electromagnetic radiation includes an accumulation detection module having a detector and configured to continuously monitor an electromagnetic radiation received by the detector; and an adaptive circuit configured to periodically interrogate the accumulation detection module; adjust a frequency of interrogation of the accumulation detection module based on an intensity of the electromagnetic radiation received by the detector; and autonomously transmit information related to an amount of the electromagnetic radiation received by the detector to a remote device.

Miniaturized, light-adaptive, wireless dosimeter systems for autonomous monitoring of electromagnetic radiation exposure and applications of same

The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameters (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).

Intraoperative monitoring of neuromuscular function with soft, tissue-mounted wireless devices

Provided herein are medical devices comprising a plurality of biologically interactive devices configured for interacting with a large area biological surface. The biologically interactive devices each may comprise a sensor for measuring a physiological parameter. A wireless controller is configured to wirelessly operate the plurality of biologically interactive devices. A wireless transmitter is configured for wirelessly communicating an output from said plurality of biologically interactive devices to a remote receiver. The medical devices are particularly suited for measuring one or both of pressure and temperature, with compatibility for incorporating additional sensors of interest.

Wireless surface mountable sensors and actuators

The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

Epidermal sensing systems for optical readout, visualization and analysis of biofluids

An electronic system for monitoring a physical parameter includes an ADM comprising an accumulation mode sensor for measuring the physical parameter by generating electrical energy associated with the physical parameter in response to a surrounding condition, and an energy storing device coupled to the accumulation mode sensor for accumulatively storing the generated electrical energy; a power source; and an SoC coupling with the ADM and the power source, configured such that the stored electrical energy is monitored, and when the stored electrical energy is equal to or greater than a pre-defined threshold, a wake-up event is generated to trigger the SoC to operates in a run mode in which the physical parameter is wirelessly transmitted to a receiver and the stored electrical energy in the energy storing device is discharged, and then the SoC returns to a sleep mode in which a minimal power is consumed.

Ultra-low power, miniaturized electronic systems for monitoring physical parameters with wireless communication capabilities and applications of same

The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems of some aspects provide for collection and/or analysis of biofluids from conformal, watertight tissue interfaces over time intervals allowing for quantitative temporal and/or volumetric characterization of biofluid release, such as release rates and release volumes.

Soft, wearable microfluidic systems capable of capture, storage and sensing of biofluids

Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device may comprise a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member and a substrate that supports the tissue penetrating members, wherein the substrate is optionally a flexible substrate.

Growing community of inventors

Champaign, IL, United States of America

John A Rogers