Herbalscience LLC

John A Pierce

Robert T Gow

Brian M Pierce

William Birdsall

George W Sypert

Dan Li

Xun Yan

Rodger M Marentis

William Julian

This invention comprises methods and compositions of. Methods of the present invention comprise extracting plant material ofso that compositions having characteristics different from those of native plant materials are obtained. Compositions comprising food aids and other dietary supplements are also taught.

[object Object]

The present invention comprises methods for making compositions derived fromspecies, particularly, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making mat&#xe9; compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native mat&#xe9; plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

The present invention comprises methods and compositions comprisingextract compositions and compositions comprising extracts ofor theobromine. Methods of the invention comprise methods of making pharmaceutical or nutriceutical products comprisingextract compositions and mat&#xe9; extract compositions or theobromine, and methods of use of the extracted products and pharmaceutical and nutriceutical products. The present invention also comprises methods for treating conditions related to mental and physical fatigue and obesity, as well as, enhancement of mental focus, cognition, and a sense of well being, comprising administering the compositions of the present invention.

Methods and compositions for oral delivery of Areca and mate' or theobromine

The present invention comprises methods for making compositions derived fromspecies, particularly, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making mat&#xe9; compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native mat&#xe9; plant materials. Further, the invention comprises methods of additional processing steps to produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

Methods and compositions comprising Ilex

A method of producing a processed kava product involves using an extraction solvent, such as liquid CO, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. A material having a preferred kavalactone distribution profile is also disclosed. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones is also disclosed.

Kavalactone profile

A method of producing a processed kava product involves using an extraction solvent, such as liquid CO, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones and other botanicals is also disclosed.

Oral delivery of a botanical

A method of producing a processed kava product involves using an extraction solvent, such as liquid CO, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones is also disclosed.

Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same

The present invention is a method for enhancing the efficacy of an active ingredient in a human comprising: administering to said human a product comprising: a kavalactone component and an active ingredient, wherein said active ingredient is selected from the group consisting of a therapeutic, a pharmaceutical, a nutraceutical and a botanical, and wherein said kavalactone component comprises a methysticin component, a dihydromethysticin component, a desmethoxyyangonin component, a yangonin component, a dihydrokavain component, and a kavain component, and wherein said kavalactone component is between about 0.1% to about 75%, by mass, of said product.

Kavalactone product

An improved method of cultivating kava plants is disclosed in which a growth medium is formed form a mound formed over a leveled bed of porous rocks, such as volcanic cinders. The bed material is substantially free of organic matter. The mound material is comprised of gravel smaller than the bed material, such as volcanic gravel, and includes organic matter. The kava plants are grown in the mound material. The plants can be harvested by lifting the plant from the mound using a modified forklift assembly. Relatively high mounded rows of other material can alternatively be used. An improved method of producing kava seedlings is also disclosed in which the apical tips of kava plant stems are cut. After buds develop along the stems, the stems are harvested, sectioned, and used to generate a large number of seedlings. Harvesting of remaining rootstock from the parent plant is delayed after harvesting of the stems to promote an increase in kavalactone concentration.

Growing community of inventors

Moreno Valley, CA, United States of America

John A Pierce