Vanderbilt University

The United States Government as Represented by the Department of Veterans Affairs

John A Oates

Olivier Boutaud

L Jackson Roberts, Ii

Ned A Porter

Irene Zagol-Ikapitte

Venkataraman Amarnath

Erica J Carrier

L Jackson Roberts

Sean S Davies

Keith T Wilson

Patricia G Yancey

Alain P Gobert

Macrae F Linton

Huan Tao

L Jackson Roberts Ii

Patricia Yancey

Macrae Linton

Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.

Compounds and methods for scavenging dicarbonyl electrophiles

A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one reactive dicarbonyl scavenger compound, or a pharmaceutically acceptable salt thereof.

Methods of preventing platelet activation

A method of treating atherosclerosis, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.

Methods for treating atherosclerosis with gamma-ketoaldehyde scavengers

A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one &#x3b3;-KA scavenger compound, or a pharmaceutically acceptable salt thereof.

Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.

Inhibitors of hemeprotein-catalyzed lipid peroxidation

Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.

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Nashville, TN, United States of America

John A Oates