Becton Dickinson and Company Limited

John A Mikszta

Jason B Alarcon

John P Dekker, Iii

Ronald J Pettis

Frank E Martin

Alexander George Lastovich

M Ishaq Haider

Vincent J Sullivan

Scott A O'Connor

Matthew S Ferriter

C Robin Hwang

Phillipe Laurent

Weston F Harding

Timothy J Erskine

Paul G Alchas

Anjana Bhuta Wills

Wendy Dale Woodley

John M Brittingham

David B Montgomery

Richard P Clarke

Zhaolin Wang

Cheryl H Dean

Brandi Ford

Robin Hwang

Andrea Waterston

Anjana Bhuta-Wills

Juan Huang

Philippe Emile Laurent

Jason Brent Alarcon

Phil G Green

James K Fentress

John P Dekker

John P Iii Dekker

Ishaq M Haider

A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

Medicament microdevice delivery system, cartridge and method of use

Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.

Microprotrusion arrays and methods for using same to deliver substances into tissue

A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35&#x3bc; and about 300&#x3bc;, and/or the powder comprises dried particles having an average mean diameter of between about 35&#x3bc; and about 300&#x3bc;. Compositions made by the above methods, and methods of using the compositions, are also described.

Pharmaceutical compositions in particulate form

The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.

Topical delivery of vaccines

An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin.

Method and device for the delivery of a substance

The present invention relates to methods and devices for administration of vaccines and gene therapeutic agents into the intradermal layer of skin.

Intradermal delivery of vaccines and gene therapeutic agents via microcannula

An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.

Microabrader with controlled abrasion features

Method and device for the delivery of a substance including a covering

A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions which may be imparted by a spring device present in the microabrader device or the motion of the operator through the handle of the microabrader device. The device may further include system and methods for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The delivered substance may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.

Substance delivery via a rotating microabrading surface

A method for delivering a substance to the epidermal tissue of skin. The method involves simultaneously disrupting only the stratum corneum of the skin and delivering the substance to the epidermal tissue of the skin.

Growing community of inventors

Durham, NC, United States of America

John A Mikszta