United States of America, As Represented by the Secretary of Agriculture

Ingredients by Nature

Other

Kgk Synergize, Inc.

John A Manthey

Najla Guthrie

Elzbieta Maria Kurowska

Robert M Brewster

Carl L Manthey

Jan Narciso

Antonio Montanari

Kyung Myung

Sylvia Horowitz

This invention relates to a flavonoid composition that includes eriocitrin. The flavonoid may be included in a complex with other bioflavonoids. The composition may also include neoeriocitrin. This invention also relates to methods of using the composition, including for reducing IL-6 or MCP-1 treating inflammation, and treating symptoms of metabolic syndrome.

Flavonoid compositions and uses thereof

This invention relates to a flavonoid composition that includes eriocitrin. The flavonoid may be included in a complex with other bioflavonoids. The composition may also include neoeriocitrin. This invention also relates to methods of using the composition, including for reducing IL-6 or MCP-1 levels, treating inflammation, and treating symptoms of metabolic syndrome.

A method for removing furanocoumarins from a liquid includes the steps of incubating the liquid with fungal hyphae for at least about two hours and removing the hyphae from the liquid by a filtration step. The furanocoumarins can be recovered from the hyphae using methods within the ordinary skill in the art. The method is useful for the removal of furanocoumarins from furanocoumarin-containing citrus juice so that the juice can be safely consumed by humans taking drugs that are metabolized by P450 CYP3A, which is the enzyme responsible for the metabolism of many widely-prescribed medications.

Furanocoumarin removal from grapefruit juice by edible fungal hyphae

Compositions and methods for the treatment, reduction and/or prevention of cardiovascular diseases and disorders are described. Individuals at high risk for developing or having cardiovascular disease or disorder may be treated with an effective dose of a polymethoxyflavone including limocitrin derivatives, quercetin derivatives, naturally occurring polymethoxyflavones, tocotrienols, and mixtures of these compounds.

Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones

A method of inhibiting the production of cytokines, particularly inhibiting the production of tumor necrosis factor&agr;, interleukin-10, and macrophage inflammatory protein-1&agr; and the like, in a mammal, including a human, in need thereof which involves administering to such mammal an effective amount, preferably cytokine production inhibiting amount, of a polymethoxylated flavone.

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Auburndale, FL, United States of America

John A Manthey