The Texas A&m University System

John A Gladysz

Kyle G Lewis

Subrata K Ghosh

Quang H Luu

In an embodiment, a composition including a chiral solvating agent to resolve nuclear magnetic resonance signals of an enantiomer of at least one analyte, where the chiral solvating agent facilitates in the at least one analyte binding to a Cface or a Cface of the chiral solvating agent, and where the chiral solvating agent causes an upfield shift or a downfield shift in at least one nuclear magnetic resonance signals corresponding to aH,F{H}, orP{H} signal, and where the chiral solvating agent includes a cobalt cation. In another embodiment, a method that includes mixing a chiral solvating agent, including a cobalt cation, with at least one analyte to form a solution, obtaining nuclear magnetic resonance spectra of the solution, and identifying an enantiomer of the at least one analyte. In some embodiments, the method further includes determining enantiomeric purities of the at least one analyte.

Chiral solvating agents

In some embodiments, the present disclosure pertains to a compound, comprising a transition metal complex having the formula &#x3a6;-[M (x,y)-L(w,v)-L(t,u)-L]AnZ. In an embodiment of the present disclosure &#x3a6; may be &#x39b;. In another embodiment &#x3a6; may be &#x394;. In some embodiments of the present disclosure, M is a transition metal. In a related embodiment, p is an integer corresponding to the oxidation state of M. In some embodiments of the present disclosure, each of x, y, w, v, t, and u independently comprise R. In other embodiments, each of x, y, w, v, t, and u independently comprise S. In an embodiment of the present disclosure, each of L, L, and Lindependently is a ligand comprising a substituted diamine. In some embodiments, Ancomprises a lipophilic anion, where m is from 1 to 3, and where Zcomprises an optional second anion.

Transition metal complexes for enantioselective catalysis of carbon-carbon, carbon-heteroatom, and carbon-hydrogen bond forming reactions

In some embodiments, the present disclosure pertains to a compound, comprising a transition metal complex having the formula &#x3a6;-[M(x,y)-L(w,v)-L(t,u)-L]AnZ. In an embodiment of the present disclosure &#x3a6; may be A. In another embodiment &#x3a6; may be &#x394;. In some embodiments of the present disclosure, M is a transition metal. In a related embodiment, p is an integer corresponding to the oxidation state of M. In some embodiments of the present disclosure, each of x, y, w, v, t, and u independently comprise R. In other embodiments, each of x, y, w, v, t, and u independently comprise S. In an embodiment of the present disclosure, each of L, L, and Lindependently is a ligand comprising a substituted diamine. In some embodiments, An&#x2033; comprises a lipophilic anion, where m is from 1 to 3, and where Zcomprises an optional second anion.

Growing community of inventors

College Station, TX, United States of America

John A Gladysz