Rutgers, the State University of New Jersey

The State University of New York

John A Gilleran

Spencer David Kimball

Darren R Carpizo

David John Augeri

Stewart N Loh

Adam R Blanden

Anthony F Bencivenga

Xin Yu

Hatim Sabaawy

The invention provides a complex comprising Znand a compound of formula (I): or a deuterated analog thereof, or an ion or poly-ion thereof, or a salt thereof that is useful for treating cancer, as well as compositions and kits comprising such complexes.

Pharmaceutical compounds and therapeutic methods

The invention provides a complex comprising Zn2+ and a compound of formula (I): or a deuterated analog thereof, or an ion or poly-ion thereof, or a salt thereof that is useful for treating cancer, as well as compositions and kits comprising such complexes.

The invention provides compounds of formula (16) and (17); and salts thereof, as well as compositions comprising such compounds and salts, complexes comprising such compounds and salts, and methods for treating cancer, inhibiting BMI1 expression, or treating Huntington's disease using such compounds, salts, and complexes. The compounds, salts, and complexes have potency, permeability, and oral bioavailability that make them particularly useful, for example, for the treatment of glioblastoma.

The invention provides compounds of formula (I): and salts thereof wherein ring A, R, HET, X, n, and Rhave any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts. 

Hydrazone derivatives for the treatment of cancer

The invention provides complexes of Zn2+ of formulae (la) and (IIa) that are useful for treating cancer, as well as compositions and kits comprising such complexes. 

Zinc complexes of hydrazones and (thio)semicarbazones and their use for the treatment of cancer

The invention provides organic complexes of Znthat are useful for treating cancer, as well as compositions and kits comprising such complexes, and intermediate monomer compounds that are useful for the preparation of such complexes.

(Thio, oxo and seleno) semicarbazone complexes with zinc and their use for treating cancer

The invention provides compounds of formula I and II and salts thereof, wherein R, R, Y, R, and Rhave any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts. 

(Thio, oxo, and seleno) semicarbazone derivatives and their use for treating cancer

The invention provides organic complexes of Znof formula (I) that are useful for treating cancer, as well as compositions and kits comprising such complexes, and intermediate monomer compounds that are useful for the preparation of such complexes. 

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New Brunswick, NJ, United States of America

John A Gilleran