La Jolla Bioengineering Institute

University of California

University of Missouri

John A Frangos

Emmanuel A Theodorakis

Sheila Ann Grant

Marcos Intaglietta

Mark A Haidekker

Lars Magnus Bjursten

Peter Sobolewski

Ramiro Contreras

Herman Sahlin

A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.

Supported molecular biofluid viscosity sensors for in vitro and in vivo use

Methods and compositions are disclosed for coating a biocompatible medical implant with a surface layer having antioxidant activity. In various embodiments, a surface layer described herein destroys the oxidative activity of a reactive oxygen species (ROS) upon contact. An ROS can be, for example, an ROS generated by neutrophils in vivo. In various embodiments, a surface layer comprises a titanium oxide layer that can comprise a rutile, an anatase or a perovskite crystal structure, and can include defects comprising Ti(III). In some embodiments, the oxide layer can further comprise a dopant such as niobium. In some embodiments, methods for forming a surface layer on a biocompatible medical implant having antioxidant activity are disclosed.

Biocompatible titanium alloys

The present invention relates to a material for implantation, which is characterised in that the surface of the material partially comprises at least one area of an inorganic, catalytical substance for improved biocompatibility of the material. Methods for the manufacturing of the material for implantation and the use thereof is also disclosed.

Material for implantation

The present invention provides for an improved in vitro tissue assembly system and related methods that includes and uses a bioreactor, a porous mandrel disposed in the bioreactor, and components that provide for the circulation of culture media and cell suspensions within the bioreactor and through the porous mandrel. The circulation of the culture media and cell suspensions within the bioreactor produces a radial, convective flow and drag forces that result in the deposition of cells on the mandrel to form a tissue construct. Upon completion of the culture and tissue formation process, the tissue construct may be removed from the mandrel for subsequent in vivo use.

Convective flow tissue assembly

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La Jolla, CA, United States of America

John A Frangos