Smithkline Beecham Corporation

Other

John A Feild

Kimberly Anne Brun

Harma Ellens

Lin Yue

Richard J Chenery

Robert S Ames

Tania Tamson Testa

Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16.

Polynucleotide and polypeptide sequence of rabbit G-protein alpha 16

Mouse OATP5 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize mouse OATP5. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: cancer, inflammation, cardiovascular disease, central nervous system disorders, auto-immune disease, and kidney and liver disease.

Polynucleotide and polypeptide sequences encoding murine organic anion transporter 5 (mOATP5)

IPT-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IPT-1 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, end stage renal disease, uremic bone disease, and cancer, among others, and diagnostic assays for such conditions.

Human sodium dependent phosphate transporter (IPT-1)

Polynucleotide encoding human sodium dependent phosphate transporter (IPT-1)

Rat mdr1b2 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rat mdr1b2. Further disclosed is method for performing a selection screen, whereby compounds are discovered that neither agonize nor antagonize rat mdr1b2.

Polynucleotide and polypeptide sequences encoding rat mdr1b2 and screening methods thereof

Polynucleotide and polypeptide sequences encoding rat mdr1b2 and

Rat cathepsin k polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rat cathepsin k polypeptides and polynucleotides in the design of protocols for the treatment of osteoporosis, periodonatal disease, arthritis, cancer, tumor metastasis, and Paget's disease, among others, and diagnostic assays for such conditions.

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Wayne, PA, United States of America

John A Feild